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7 Cards in this Set
- Front
- Back
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causes of birth defects
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65-85% unknown/multifactoral
10-25% genetic 10% environment mom exposure >1% |
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meds implicated in birth defects
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ACE, NSAID, Valproate
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fetal therapies
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surgery:
-sp bifida -thoracic shunt -thransfusion -diaphrag hernia medical: -21 hydroxylase -fetal arryth stem cell/BM trsplt: -immunodeficiency synd |
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prenatal diagnosis options
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preimplantation
CVS & early amnio 10-12 (15) wks amnio 20 wks PUB after 20 wks, higher risk |
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general risk of pregnancy loss w/amnio/CVS
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.6% (increased by .5% over preg in general)
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pitfalls of prenatal diagnosis
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invasive
unknown dvt of defects limited tx options uses resources |
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maternal serum screening
(by trimester) |
1st trimester
-PAPP A & hCG 2nd trimester -triple marker (AFP, chorionic gonadotropin, E3) -Quad (above + inhibin) |
