Repro - Path - Female

Front 1

epithelium in outer portion of the cervix:

epithelium in endocervical canal:

Stain to see transformation zone:

How much of the endometrium cycles?

How to tell if the layer is luteinized:

Back 1

strat squamous

simple columnar, mucus producing

iodine - to stain glycogen

2/3 - other 1/3 (basal layer) stays

get bigger, pale staining from lipids (steroids)

Front 2

Why do women have orgasms?

Cells with multiple giant cells, characteristic inclusion are diagnostic for:

follicular cervicitis w/ germinal centers, chronic endometritis w/ plasma cells, PID:

Skene's/Bartholin's abscesses, purulent cervicitis, acute endometritis w/ neuts:

Back 2

make the oviducts wiggle, catch the egg

HSV II

Chlamydia

Gonorrhea

Front 3

major cause of chancroid in the vulva;

bacterial vaginosis, vaginal pH is more alkaline, confirm by a drop of KOH, fishy smell, clue cells:

Red itchy rash, fungal colonies:

bad smelling, strawberry inflammation, thin discharge:

Back 3

H. ducreyi

Gardnerella

Candida

Trichomonas - looks like bouncing pear on wet prep

Front 4

Pathology of vulvar vestibulitis:

How to distinguish Bartholin, Gartner duct, and mucin gland cysts:

Mysterious process where you see a band of loose, pale-staining homogeneous collagen under the epidermis, skin turns gray, itchy:

Back 4

too many nerves, too many mast cells

Bartholin - stratified/transitional epithelium
Gartner - one layer of non-mucinous epithelium
mucin gland - one layer of mucinous epi

lichen sclerosus

Front 5

large, multiple warts on vulva, perianal region, vagina, cervix:

Microscopic appearance:

Which HPV strains cause genital warts?

HPV's that cause squamous carcinoma:

Back 5

condyloma acuminatum

branching fibrous stalk, thickened epithelium w/ hyperkeratosis, parakeratosis, or koilocytes (dx of HPV)

6, 11

16, 18

Front 6

Most common type of vulvar squamous carcinoma:

mucin-rich cancer cells grow within epidermis of vulva, perineum:

only common non-iatrogenic birth defect:

only common non-infectious, non-malignant acquired lesion of the vagina;

Back 6

keratinizing

Extramammary Paget's disease

septate vagina - mullerian ducts don't fuse

Gartner duct cyst

Front 7

Why is it called "clear cell" adenocarcinoma?

sarcoma that contains strap- or tadpole-like cross-striated rhabdomyoblasts;

Endocervical glands plugged by inflammation:

Back 7

glycogen-rich

embryonal rhabdomyosarcoma

Nabothian cysts

Front 8

microglandular hyperplasia results from what?

Average number of cells on a Pap smear, liquid prep:

virulence factor in SCC of the cervix, and what do they bind:

Difference between CIN I, II, III:

Back 8

progesterone stimulation of endocervix

Pap - 10,000
liquid - 5,000

E6, E7 - bind p53, Rb

I - koilocytes only
II - atypical cells in lower portions, normal maturation toward surface
III - cells no longer mature toward surface (carcinoma in situ)

Front 9

Immunostaining for microinvasive carcinoma:

strongly overexpressed in premalignant/malignant cervical cells:

Pap smear markers for proliferation:

Back 9

keratin, collagen IV, laminin

p16INK 4a

ProExC, MIB-1

Front 10

Infection of the endometrium is usually due to:

infamous, lethal complication of self-abortion

plasma cells in endometrium:

stain for plasma cells:

endometrium outside of the uterus, and most common site;

Back 10

retained products of conception

C. perfringens

chronic endometritis

syndecan-1

endometriosis, ovary

Front 11

Two drugs that help prevent endometriosis:

Minor lesions look like:

"chocolate cysts":

tipoff for endometrial polyps:

Back 11

OC's, metformin

powder burns under the serosa

longstanding ovarian lesions

presence of thick-walled vessels

Front 12

Difference between simple, complex, and atypical endometrial hyperplasia:

Most common gynecologic cancer:

Risk factors:

Back 12

simple - glands of uneven size, cystically dilated glands, no anaplasia
complex - crowded, irregular-shaped glands
atypical - crowded, irregular, anaplastic cells ("tufting" cells)

endometrial adenocarcinoma

extra estrogen, diabetes, HTN, infertility, endometrial hyperplasia

Front 13

Which stage is more ominous:

Amplification of what is a strong predictor of bad outcome for papillary serous adenocarcinoma?

rubbery, white spherical tumors, "whorled silk" pattern on cross section:

how to recognize a leiomyosarcoma:

Back 13

G3 - solid sheets

HER-2, neu

leiomyomas

smooth muscle tumor of uterus w/ >10 mitotic figures on high power field, anaplasia