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24 Cards in this Set
- Front
- Back
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Antimetabolites
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Methotrexate
MOA - competitive inh and reversible DHRF inhibitor Uses - Solid tumors AE/CI - PREGNANCY |
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Alkylating agents
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Cyclophosphamide
Cisplatin Carboplatin Temozolamide |
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Cytotoxic Abx
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Doxorubicin
MOA - prevents TOPOII from resealing --> free radical formation Uses - Solid tumors of breast, endometrium, testes and lung; ABVD in Hodgkin's, CHOP in non-Hodgkins, sarcomas, osteogenic, Ewing's, metastatic of thyroid Tox - serious cardiomyopathy ANTIDOTE - Dexrazoxane Bleomycin MOA - fragmentation of DNA Uses - Testicular cancer, sq carcinoma of head, neck and lungs, lymphomas Tox - pulmonary tox |
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Natural Products
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Etoposide
MOA - stabilizes topoisomerase II Uses - small cell cancer, testicular cancer AE - AML Paclitaxel MOA - inh microtubules disassembly and microtubular plates Uses - ovarian and breast cancer Tox - HS rxns, neutropenia, cardiac conduction |
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Hormones and Antihormones
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Ethinyl estradiol
Fulvestrant Tamoxifen Anastrozole Flutamide Finasteride Leuprolide Prednisone Mifepristone Oxandrolone Spironolactone (hCG) marker Testosterone |
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Others
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Zoledronic acid
Pamidronate Trastuzumab Bisphosphonate (AFP) marker |
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Cyclophosphamide
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MOA - strong electrophiles, affects DNA and RNA syn
Uses - leukemia, solid tumor - breast, non-hodgkin's, ovarian, neuroblastoma Metabolites - mustard and acrolein Tox - Nephrotoxic (give demecocycline) and hemorrhagic cystitis (give Mesna) |
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Cisplatin
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MOA - inh replication and transcription
Uses - urinogenital cancers - testicular, ovarian, bladder Tox - Nephrotoxic, ototoxic GIVE AMIFOSTINE |
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Temozolamide
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MOA - damages DNA
Uses - malignant gliomas and melanoma CI - Preg |
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Carboplatin
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MOA - inh replication and transcription
Uses - ovarian cancer, head, neck, and lung cancer AE - myelosuppressive |
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Zoledronic Acid
Pamidronate Bisphosphonate |
MOA - inhibits osteoclasts; inhibits activation of enzymes that utilize pyrophosphate
Uses - multiple myeloma, prostate cancer, osteoporosis AE - fatigue, anemia, muscle aches, fever, swelling and feet or legs; esophageal and stomach irritation CI - renal disease |
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AFP marker
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tumor marker
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Trastuzumab
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MOA - recombo DNA derived humanized monoclonal Ab (G1 kappa)
Uses - specific breast cancers AE - cardiotoxic |
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Ethinyl Estradiol
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MOA - activates estrogen receptor
Uses - OCPs, menopausal sxs, female hypogonadism |
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Tamoxifen
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MOA - blocks binding of estrogen to its receptor
Uses - breast cancer and prophylaxis, gynecomastia AE - tox - N/V, hot flashes, vaginal bleeding, disease flare, hypercalemia, ocular dysfxn, peripheral edema |
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Anastrozole
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MOA - aromatase inhibitor prevents production of estrogen
Uses - Breast cancer |
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Flutamide
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MOA - nonsteroidal androgen antagonist which inhibits translocation of steroid receptors to nucleus
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Finasteride
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MOA - 5-alpha reductase inhibitor inhibits synthesis of dihydrotestosterone
Uses - Prostate cancer |
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Leuprolide
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MOA - GnRH analogue which acts as partial agonists at GnRH receptor; constant doses = inhibit release of LH and FSH
Uses - Prostate cancer |
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Mifepristone
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MOA - progesterone receptor antagonist, glucocorticoid receptor antagonist
Uses - Cushing's Syndrome, MABs, uterine fibroids, endometriosis, breast/ovarian/prostate cancer |
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Oxandrolone
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MOA - anabolic steroid derived from DHT; does not aromatize or influence body testosterone; high doses decrease LH production
Uses - muscle regrowth in d/o that cause involuntary wt loss like HIV/AIDS, partially successful in txing osteoporosis |
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Spironolactone
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MOA - inhibits aldosterone, androgen production
Uses - anti-androgen, diuretic AE - gynecomastia, impotence, ED, hyperkalemia |
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hCG marker
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tumor marker for seminoma, choriocarcinoma, germ cell tumors, hydatidiform mole, teratoma, islet cell tumor, testicular cancer
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Testosterone
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Uses - promotes male 2ndary characteristics, prevents osteoporosis
AE - accelerating prostate cancer, infertility |
