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8 Cards in this Set
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Most common viral STD in US:
type of virus: Clinical features, S/S: Subtypes for benign lesions, premalignant lesions: |
HPV
dnDNA, non-enveloped chronic infections; causes benign warts, can cause epithelial cancer soft, moist, pink lesions; benign - condyloma acuminanta; malignant - flat condyloma, CIN benign - 6, 11 premalignant - 16, 18 |
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Control of HPV:
19 y/o with fever, genital pain, cluster of vesicular lesions on penis: type of virus: Where does HSV stay latent? oral > genital: primarily genital: |
vaccine - Gardasil - against 6, 11, 16, 18
HSV dnDNA, enveloped ganglia HSV-1 HSV-2 |
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Most common type of HSV infection:
Recurrences of HSV are prevented by what? What are Cowdry type A inclusions? Tx? |
usually asymptomatic
cellular response - CD4, CD8 accumulation of viral proteins in nucleus Acyclovir, Valacyclovir PO |
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% of US adults with HSV-1, HSV-2:
prevalence of HIV in US: 75% of HIV infections are from: CD4 count below what = crisis? Tx for HIV: |
HSV-1 - 70%
HSV-2 - 20% 1 million sexual contact <200 HAART - NRTI's, NNRTI's, PI's |
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Explain Hepatitis serotyping:
HBsAg HBsAb A-HBc IGM A-HBc IGG HBeAg A-HBe HBV-DNA |
HBsAg - general marker of infection
HBsAb - recovery/immunity to HBV A-HBc IGM - marker of acute infection A-HBc IGG - chronic infection HBeAg - active viral replication A-HBe - virus not replicating HBV-DNA - more accurate, active viral replication |
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Prevention of HBV involves what?
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active vaccine - routine in infants, children, high risk adults
passive vaccine - HBIG for post exposure, HCW's, infants born to HBV+ mothers screening of blood products |
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HCV virus family:
HCV - leading cause of what? What % of chronic liver disease is HCV related? Most common risk factors for HCV? What promotes severity of HCV infection? |
Flavivirus
liver transplantation 40% IV drug use, multiple partners EtOH use, Age >40 y/o, HIV, male, HBV coinfection |
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Diagnostic test for HCV:
Explain HCV serologies: Anti-HCV, normal LFT's Anti-HCV, elevated LFT's Anti-HCV, HCV RNA Negative Anti-HCV, elevated LFT's |
serologic presumptive dx - EIA
Anti-HCV ELISA - initial dx/screening HCV RIBA - confirmatory dx HCV PCR qual - confirms HCV HCV PCR quant - assesses viral load Anti-HCV, normal LFT's - infected/exposed; if elevated LFT's, then infected Anti-HCV, HCV RNA - infected neg Anti-HCV, elevated LFT's - "window period" - check RNA |
