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8 Cards in this Set
- Front
- Back
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FSH
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tropic for sertoli cell (create ABP + aromatase); upregulates LH receptors on Leydig cellsno activity until puberty where begin with nocturnal and then increase
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LH
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action on interstitial leydig cells to convert chol --> T; no activity until puberty where begin with nocturnal and then increase
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Estradiol (E2)
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in pituitary, decreases amplitude of LH/FSH
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GnRH
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circadean release (highest in AM) + pulsatile (90-120 min), self priming (increased binding sites during troughs), flare effect (increased LH/FSH secretion w/ initial effect), too frequent pulses (leuprolide) --> GnRH down regulation + low LH/FSH
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Testosterone
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regulates spermatogenesis; enters sertoli cells and is bound to ABP in seminiferous tubules (mediated by FSH); male sex drive/performance, muscle mass increase, penis enlargement, vocal cord enlargement
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Inhibin B
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inhibits GnRH production (activin stimulates, follastatin inhibits); decreases FSH secretion over LH secretion
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DHT
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masculinizes the external male genitalia, increased facial/body hair, acne, scalp hair recession, prostate enlargement, skeletal growth/epiphysela closure, stimulates lean body mass, stimulates eryhropoietin/clotting factor production, decreases HDL levels
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hCG
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in male fetus, controls development of testes/male internal duct structures
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