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10 Cards in this Set
- Front
- Back
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what categories of genes are most important to PGx?
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drug metabolizing enzymes (CYP450)
drug targets (VKOR --> warfarin response) HLA subtypes (hypersensitivity rxns) |
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what enzyme metabolizes warfarin?
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CYP2C9
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what enzyme metabolizes clopidogrel?
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CYP2C19
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what enzymes metabolizes tamoxifen?
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CYP2D6
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what enzyme metabolizes codeine?
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CYP2D6
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what are the CYP metabolizer categories?
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poor (no enzyme activity)
intermediate (reduced enzyme activity) extensive (normal activity) ultrarapid (increased enzyme activity) |
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what does warfarin inhibit?
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VKOR (Vitamin K Epoxide Reductase)
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what are the implications of CYP2C9*2 and CYP2C9*3 causing increased sensitivity to warfarin?
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lower mean doses to achieve INR
longer times to stabilization of INR higher risk of bleeding |
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What SNP in VKOR1C is assoc w/ increased warfarin sensitivity?
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1639 A/G
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what is the best marker of warfarin effect?
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PT (INR)
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