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21 Cards in this Set
- Front
- Back
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Continuous GnRH
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↓LH and ↓FSH
Precocious Puberty |
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Pulsatile GnRH
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↑LH and ↑FSH
Infertility |
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Leuprolide
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GnRH analog
Pulsatile admin= agonist properties for infertility Continuous admin= antagonist properties for prostate cancer Tox: antiandrogen, nausea, vomiting |
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Testosterone
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Agonist at androgen receptors
Hypogonadism, Development of 2° sex characteristics, Stimulate anabolism after burns Tox: gonadal atrophy, premature closure of epiphyseal plates, ↑LDL, ↓HDL |
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Finasteride
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5α-reductase inhibitor= ↓DHT
BPH, Propecia SE: gynecomastia |
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Flutamide
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NONSTEROIDAL competitive testosterone receptor antagonist
Prostate Carcinoma |
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Ketoconazole
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Desmolase inhibitor= ↓steroid synthesis
Polycystic Ovarian Syndrome, Hirsutism SE: gynecomastia, amenorrhea |
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Spironolactone
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Steroid receptor antagonist
Polycystic Ovarian Syndrome, Hirsutism SE: gynecomastia, amenorrhea |
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Ethinyl Estradiol
DES Mestranol |
Estrogens
Hypogonadism, ovarian failure, Hormone Replacement Therapy in post-menopausal, androgen dependent prostate cancer Tox: endometiral cancer, thrombus Contra: history of DVTs, estrogen receptor+ breast cancer |
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Clomiphene
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Partial estrogen receptor agonist in hypothalamus= ↑LH & FSH
Infertility, PCOS SE: hot flashes, multiple simultaneous pregnancies, visual disturbances |
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Tamoxifen
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Estrogen Receptor Antagonist on breast tissue
ER+ breast cancer |
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Raloxifene
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Estrogen Receptor Agonist on bone= ↓resorption of bone
Osteoporosis |
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Anastrozole
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Aromatase inhibitor
Breast Cancer in postmenopausal women |
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Exemestane
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Aromatase inhibitor
Breast Cancer in postmenopausal women |
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Mifepristone
(RU-486) |
Competitive progesterone receptor antagonist
Termination of pregnancy Admin w/ Misoprostol (PGE1) Tox: heavy bleeding, GI effects |
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Dinoprostone
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PGE2 analog= cervical dilation and uterine contraction
Induce Labor |
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Ritodrine
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β2 agonist= relaxes uterus
Premature uterine contractions |
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Terbutaline
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β2 agonist= relaxes uterus
Premature uterine contractions |
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Tamsulosin
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α1A and α1D antagonists= ↓prostate smooth muscle contraction
BPH |
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Sildenafil
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Inhibit cGMP phosphodiesterase= ↑cGMP
Erectile Dysfunction Tox: Headache, Heartburn, Hypotension, Flushing, Blue-green vision |
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Vardenafil
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Inhibit cGMP phosphodiesterase= ↑cGMP
Erectile Dysfunction Tox: Headache, Heartburn, Hypotension, Flushing, Blue-green vision |
