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11 Cards in this Set
- Front
- Back
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physiology of menopause
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used up all follicles - FSH and LH can't act on follicles to make estrogen
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mean age for menopause
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50
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early menopause assoicated with
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smoking (increases metabolism of esterogen)
low body weight (low esterogen production) poor nutrition/chronic infection (low estrogen production) |
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late menopause associated with
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obesity (estrogen production from adipose tissue)
diabetes endometrial and breast cancer |
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estrogen source during postmenopausal state
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synthesized from androstenedione and testosterone in adipose tissue
less serum hormone bindling globulin - means more free steroid |
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estrogen effects (nonreproductive)
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bone growth and prevention of calcium resorption from cortical bone
decreased LDL, increased HDL maintain mucosa and connective tissue |
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physio of bone remolding after menopause
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decreased estrogen means more osteoclasts than osteoblasts
osteoblasts to produce RANK ligand which binds osteoclasts to and increases lifespan and maturity of of osteoclasts - in menopause there is more RANK release lack estrogen means means more breakdown than formation |
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major cause of death due to menopause
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cardiovasulcar disease
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raloxifene
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estrogen ANTagonist at uterus and breast
estrogen AGONIST at bone |
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when should you give estrogen after menopause
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if there is sig risk for osteoporisis
hot flashes, urogenital symtpoms |
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risks with taking estrogen
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venous thrombosis
breast cancer stroke *use the lowest does of estrogen in the shortest time peroid |
