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7 Cards in this Set
- Front
- Back
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ACE and ARB Mechanism of Action
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ACE Inhibitors
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-pril
Captopril; only ACE-I with a sulfyl moiety All pro-drugs except Captopril and Lisinopril Long t1/2; except Captopril (~2hrs) |
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ARBs
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-sartan
Only two pro-drugs (esters); Candesartan and Olmesartan -> activated in intestinal epithelium |
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ACE/ARB Side effects
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Dry cough; due to increase in Bradykinin, less common with ARBs
Angiodema; due to increase in Bradykinin, common in face, tounge, lips and throat (can cause airway constriction). Less common with ARBs Hyperkalemia; contraindicated in patients taking K+ supplements or those on K+ sparing diuretics -pair with Thiazide to offset increase in K+ |
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ACE/ARB Contraindications
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Bilateral renal artery stenosis
Prior angiodema Pregnancy |
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Direct Renin Inhibitors
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Aliskiren
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Drug Summary
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