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18 Cards in this Set

  • Front
  • Back

Function of renin-angiotensin aldosterone
system?

Regulation of blood flow to and within the kidneys

What triggers the renin-angiotensin aldosterone
system?

changes in blood pressure and plasma sodium; monitored by the juxtaglomerular apparatus

Effect of low plasma sodium?

decreases water retention in the circulatory system ---> decrease in blood volume ---->


decrease in blood pressure

Tubular reabsorption

kidney reabsorbs essential substances and water from ultra filtrate and returns them to the
bloodstream

occurs in proximal and distal tubules and loop of henle

Substances reabsorbed by active transport

  • glucose, amino acids, and salts

  • chloride
  • sodium

Substances reabsorbed by passive transport

  • Water
  • Urea
  • Sodium

angiotensin II

Major effector peptide


displays opposing actions at different receptors (AT1 and AT2)


AT1 receptor

vasoconstriction, antinatriuresis, bp increase

AT2 receptor

vasodilation, natriuresis, bp decrease

Maximal Reabsorptive Capacity

maximal concentration of a substance
dissolved in the blood above which the
kidneys filter it into the urine

Renal Threshold

Describes the plasma concentration at which
active transport stops

compare RT to plasma - what does it tell you?

compare RT to plasma concentration can distinguish between excess solute
filtration and renal tubular damage

Glucose renal threshold

Glucose in the urine with a normal blood
glucose level suggests tubular damage and not
diabetes mellitus

ADH function

makes the walls of the distal convoluted tubule and collecting ducts permeable or impermeable to water, controlled by state of hydration of body

Aldosterone

regulates reabsorption of sodium in distal tubule, controlled by sodium levels in body

High ADH levels

Increased permeability ---->


increased reabsorption of water ---->


low volume, highly concentrated urine w/ HIGH specific gravity

Low ADH levels

Decreased permeability ---->


decreased reabsorption of water ---->


high volume of dilue urine with LOW specific gravity

Peritubular capillaries

  • capillaries surrounding proximal tubules
  • sight of removal of medications and foreign substances from blood to ultrafiltrate