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9 Cards in this Set
- Front
- Back
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What is the first line drug for immunosupression? What does it do?
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Calcineurin inhibitors --> inhibit T-cell activation? Cyclosporine and tacrolimus
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What are the side effects of calcinuerin inhibitors?
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they have CYP450 interatction and nephrotoxicity
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What is the MOA of Cell Cept (motefil)?
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T&B cell production
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What is the 2nd line drug for immunosupression?
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Sirolimus --> Macrolide Abx
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What is a major risk of Azathioprine?
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squamous cell carcinoma
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What is the major effect of corticosteroids?
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They block the expression of several interleukins
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What are the longterm complications of transplant?
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Opportunistic organisms
CMV Brain infections Neoplasia (post-transplant lymphoma) CV disease hyperlipidemia |
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When does Chronic Rejection occur? What are the signs?
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7 to 10 years later
progressive azotemia proteinuria HTN ALL parts of the kidney parenchyma are involved |
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Why does hyperacute rejections occur?
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The recipient has preformed Ab's against the donor
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