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8 Cards in this Set
- Front
- Back
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Basket-weave type glomerular basement membrane (thickened and split) on EM
DX? |
Alport's (plus sensorineural deafness and/or ocular)
Hereditary Nephritis X linked or autosomal recessive (homozygous on 3 and 4 COL4 genes) |
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Heterozygous 3 and 4 COL4 mutations
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thin glomerular basement membrane
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Presentation of thin GBM disease
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asymptomatic microscopic hematuria
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Acute posstreptococcal glomerulonephritis
Describe histopathology |
endothelial and mesangial proliferation
hypercellular neutrophil and monocyte infiltration low c3 in pasma granular appearance of basement membrane --starry sky appearance due to immune complex deposition subepithelial deposits-'humps' ACUTE DIFFUSE PROLIFERATIVE GLOMERULONEPHRITIS usually about 2 weeks following an infection with nephritogenic strain of Step beta hemolytic, group A Will see elevated ASO titers. |
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Berger's disease
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IgA glomerulopathy
following exposure to viral, dietary, or bac antigens IgA- complexes accumulate in mesangium and activate alternative complement system mild disease-normal glomerulus severe disease-focal proliferative glomerulonephritis IF-key diagnostic- staining for IgA-C3 in the mesangium presentation: mild- asymptomatic hematuria severe- nephritic/nephrotic syndrome Clinical course: EPISODIC RECURRENCES!!!!! |
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Double contouring of GBM
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type I membranoproliferative gromerulonephritis
common in older children associated with chronic infections HBV, HCV, also cryoglobulinemia |
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Mesangium hypercellularity with IgA complexes
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Berger's disease
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Dense depostis disease
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membranoproliferative glomerulonephritis type II
IgG antibody against C3 nephritic Factor you will see severe hypocomplimentemia coarsely granular and confluent bands of capillary wall staiing for C3 riboonlike dense zones |
