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6 Cards in this Set
- Front
- Back
- 3rd side (hint)
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PKD
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Polycystic kidney disease.
Enlargement with hundreds to thousands of cysts, and renal failure in 5th decade. |
Occurs in 1/800
85-90% are mutations in PKD1 10-15% are mutation in PKD2 Accounts for 10% end-stage renal disease |
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Nephrotic Syndrome
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Proteinuria > 3.5 g/day
Increased glomerular capillary permeability and podocyte process effacement |
Often presents with hypoalbuminemia
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Alport's Syndrome
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Irregular basement membrane thickness, fails as filter.
Presents with hematuria progressing to glomerulonephritis |
85% X-linked mutation of COL4A5 (encodes type IV collagen)
1-2% of end-stage renal disease |
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Fanconi's Syndrome
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Acidosis
Oseomalacia Glucosuria Hypokalemia |
Impaired ability of PT to reabsorb HCO3-, AA, glucose, and low MW proteins.
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Proteinuria (most common causes)
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Filtration w incomple reab
TAL cells produce and secrete Tamm-Horsfall glycoprotein |
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Bartter's Syndrome
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Hypokalemia, metabolic acidosis, and hyperaldosteronism.
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Inact mutation is NKCC2, ROMK, or ClCNKB decrease TAL reab of Na and K. ECF decreases, stimulation aldosterone -- NaCl reab in DT and CD.
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