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10 Cards in this Set
- Front
- Back
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#1 cause of nephrotic syndrome in kids?
in adults? in African Americans? Worldwide? |
Kids: Minimal change disease
Adults: Membranous GN Af Am: Collapsing FSGS Worldwide: IgA nephropathy |
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Associations with FSGS
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HIV
Heroin Obesity Unilateral agenesis Most are idiopathic |
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Associations with membranous GN?
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Solid tumors
Diabetes HBV, HCV, Syphilis, Malaria Lupus Drugs (Gold, Penicillamine, NSAIDs) |
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NSAIDs associated with which 4 renal diseases?
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Minimal change disease
Membranous glomerulopathy Papillary necrosis / Analgesic nephropathy Acute interstitial necrosis |
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Gene in ARPKD?
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PKHD! chromosome 6
Fibrocystin |
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Gene in ADPKD?
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PKD1 (16) polycystin 1
PKD2 (4) polycystin 2 |
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Clinical features of ADPKD
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Massive kidneys
Bilateral Liver MVP (25%) berry aneurysm (8%) |
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HCV associated with what 3 renal diseases?
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MPGN
MGN Cryo-GN |
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Gene in Alport's?
clinical? EM? |
Mutation COL4A5 xq22
Collagen IV alpha chain 5 usu XR Nephritis & sensorineural deafness Thickening and attenuation of GBM & TBM Moth-eaten |
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Other disease of collagen IV in kidney?
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Thin basement membrane disease (benign familial hematuria)
Dx on EM: THINNING OF GBM Mutation COL4A4 gene, alpha 3& 4 chains |
