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16 Cards in this Set

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FUNCTIONS OF KIDNEY

1. Excretion of waste products


2. Regulation of H20 and Na


3. Maintenance of acid/base balance


4. Secretion of hormones

E_R_M_S

Diseases of the kidney

Glomeruli


Tubules


Interstitium


Vessels

Azotemia

Increase BUN & Creatinine

Uremia

Azotemi + more problems

Acute renal failure

Oliguria

Chronic Renal Failure

Prolonged uremia

Nephrotic Syndrome

Massive proteinuria(>3.5g/day)


Hypoalbuminemia


Edema


Hyperlipidemia/-uria

Nephritic syndrome

Hematuria(<3.5g/day)


Oliguria


Azotemia


HTN

Minimal change disease

#1 cause of nephrotic syndrome in CHILDREN


Loss of foot processes


Pathogenesis unknown


GOOD PROGNOSIS

Focal segmental glomerulosclerosis

Primary or secondary


Some(focal) glomeruli show partial (segmental) hyalinization


Pathogenesis Unknown


POOR prognosis

IgA nephropathy

Common


Child with Hematuria after URI


IgA mesangium


Variable prognosis

Pyelonephritis

Invasive kidney infection


Usually ascends from UTI


Fever, flank pain


Organisms: E.coli, Proteus

Urinary tract infection

Women, Elderly


Patiens with catheters or malformations


Dysuria, frequency


Organisms: E.coli, Proteus

Drug-induced interstitial nephritis

Antibiotics, NSAIDS


IgE and T-cell mediated reaction


Fever, eosinophilia, hematuria


Patient usually recovers


Analgesic nephritis is different (bad)

Acute tubular necrosis

The most common ARF


Reversible tubular injury


Many causes: Ischemic (shock), toxic (drugs)


Most of patients recover

Benign nephrosclerosis

Found in patients w/ benign HTN


Hyaline hickening of arterial walls


Leads to mild functional impairment


Rarely fatal