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12 Cards in this Set
- Front
- Back
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What are the hallmarks of membranous nephropathy?
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Adults with protenuria. edema (due to the protinuria), possibly coagulation problems.
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What is unique about the deposition of Ig in membranous nephropathy?
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They deposit in the subepethelal space.
Since this is remote from the plasma (where the compliment is), the actual glomerulus isn't dramatically altered and appears normal on microscopy. |
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List four groups of secondary causes for membranous nephropathy.
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Cancers (lung, lymphomas, colon)
Infections (malaria, hep B and C) Drugs (Penicillamine, gold) Immunologic (SLE) |
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A child presents with edema and protinuria. What is the most likely disease?
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Minimal change disease.
I bet there's minimal change in the disease. |
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What is the only real change in minimal change disorder?
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Podocyte effacement (only seen on SEM)
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This was seen in a child with protinuria. What is it?
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Minimal change disease. You don't actually biopsy these kids.
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What is used to treat MCD?
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Roids
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What is the most common cause of nephrotic syndrome in African Americans?
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Focal and Segmenting Glomerular Sclerosis (FSGS)
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How does FSGS progress?
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It starts in the medulary glomerulus and progresses in a random pattern throughout the kidney with tubular atrophy and interstitial fibrosis.
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What causes are there for FSGS?
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Idiopathic
AIDS (Collapsing FSGS) Genetic (seen in children) Adaptive response to renal damage |
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Of the big three nephrotic syndromes which are most common in adults?
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Membranous Nephtopathy
FSGS |
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What lesions are typical in the kidney of diabetic nephropathy?
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Diffuse and nodular glomerular lesions
Atherosclerotic vessels Pylonephritis lesions |
