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6 Cards in this Set
- Front
- Back
- 3rd side (hint)
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Where are the three cells located in the glomerulus?
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Mesangial Cells
Podocytes Endothelial Cells What are their functions? |
Mesangial Cells - Regulation of perfusion via contraction
Podocytes - Filtration slit formation and establishment of membrane charge barrier Endothelial Cells - Diaphragm formation and filtration |
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What are 2 ways in which immune complexes may stay in the kidney to trigger glomerulonephritis?
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Direct binding to basement membrane cells. (Immune specific, TII)
Getting stuck in the glomerulus due to high concentration created elsewhere. (phagocytic overload, TIII) |
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What is the difference in reaction when Ig's bind to the proximal versus distal GBM?
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Proximal - Ig's bind to the blood side and cause an inflammatory rxn (nephritic syndrome)
Distal - Non-inflammatory attack of podocytes from the urinary side (nephrotic syndrome) |
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What are the pathological mechanisms and symptoms of a nephritic syndrome?
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Pathological Basis - Direct attack of proximal glomerulus by PMN's causing holes in the membrane and vasoconstriction.
Symptoms - Hematuria, Mild Protinuria, Renal Failure |
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What are the pathological mechanisms and symptoms of a nephrotic syndrome?
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Pathology - Antibodies bound to the basal surface of epithelial cells induce podocyte damage and retraction. This leads to a break down of the charged nature of the lamina media.(non-inflammatory, PMN's and lymphos can't get in to attack)
Symptoms - Severe protinuria |
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What factors make immune complexes more likely to get trapped in the kidney?
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High Quantity
Small-Medium Size What does charge determine? |
The location of binding.
Highly (+) Ig will bind to the sub-epithelial while highly (-) Ig binds sub-endothelial |
