Reading...
Play button
Play button
Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
21 Cards in this Set
- Front
- Back
|
Substance secreted in PCT
|
Ammonia (buffers for secreted H+)
|
|
|
Transporters on BL side in PCT
|
Na+/K+ exchanger (Na+ into blood)
HCO3- transporter (into blood) |
|
|
Apical transporters in PCT
|
Na+/H+ exchanger (Na+ influx, H+ efflux)
Na+/(glucose/aa/phosphate) symporters |
|
|
Intracellular and brush border CA activity
|
1) Intracellular CA: makes HCO3- and H+
2) H+ exchanged into lumen for Na+, HCO3- reabsorbed 3) H+ binds to urine HCO3- --> water and CO2 (bb-CA) 4) Diffuse into cell |
|
|
PTH effect in PCT
|
Inhibits Na+/phosphate symporter --> increase phosphate excretion
|
|
|
Ang-II effect in PCT
|
Stimulates Ha+/H+ exchanger --> increase Na+, HCO3-, water reabsorption
|
|
|
Thin descending LoH activity
|
Passive reabsorption of water due to medullary hypertonicity; concentrating segment - urine hypertonic
|
|
|
Thick ascending LoH activity
|
Active reabsorption of Na+, Cl-, K+
Paracellular reabsorption of Mg2+, Ca2+ (via K+ potential) Makes urine less concentrated |
|
|
BL transporters in thick ascending LoH
|
Na+/K+ exchanger (Na+ into blood)
K+ and Cl- ion channels |
|
|
Apical transporters in ascending LoH
|
Na+/K+/Cl- cotransporter
K+ channel (into lumen) |
|
|
DCT activity
|
Active reabsorption of Na+, Cl-
Urine becomes hypotonic |
|
|
BL transporters in DCT
|
Na+/K+ exchanger (Na+ into blood)
Na+/Ca2+ exchanger (Ca2+ reabsorbed into blood) Cl- channel (reabsorbed) |
|
|
Apical transporters in DCT
|
Na+/Cl- cotransporter
Ca2+ channel (influx) |
|
|
PTH effect on DCT
|
Increase Na+/Ca2+ exchanger activity --> increase Ca2+ reabsorption
|
|
|
CT principal cell activity
|
Na+ reabsorption
K+ secretion Water reabsorption (via aquaporins) |
|
|
BL transporters in CT principal & intercalated cells
|
Principal: Na+/K+ exchanger, V2 receptor
Intercalated: HCO3-/Cl- exchanger (HCO3- reabsorbed) |
|
|
Apical transporters in CT principal & intercalated cells
|
Principal: Na+, K+ channels, aquaporins
Intercalated: H+ ATPase |
|
|
Aldosterone effect on CT
|
Increase N+ channels on apical/luminal side in principal cells
|
|
|
ADH effect on CT
|
Bind to V2 receptor --> Increase aquaporins on apical/luminal side of principal cells
|
|
|
Urine tonicity in PCT, LoH, DCT, CT
|
PCT: isotonic
DLoH: hypertonic ALoH: less hypertonic DCT: hypotonic CT: hypotonic |
|
|
Na+ percentage reabsorbed in PCT, LoH, DCT, CT
|
PCT: 65-80%
DLoH: none ALoH: 10-20% DCT: 5-10% CT: 3-5% |
