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5 Cards in this Set
- Front
- Back
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PTH
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Stimulus for secretion: decrease in plasma calcium conentration
Time Course:fast Mechanism of action: Basolateral receptor. adenylate cyclase. cAMP--> urine Actions on Kidneys: decrease the phosphate reabsoprtion in the proximal tubule and increase the calcium reabsorption in the distal tubule. stimulates 1 alpha hydroxylase in the proximal tubule |
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ADH
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Stimulus for secretion: increased plasma osmolaity and decreased blood volume
Time Course: fast Mechanism of action: basolateral V2 receptor. Adenylate Cyclase. cAMP. NOTE- V1 receptors are located on blood vessals and their mechanism is calcium and IP3 Actions on Kidneys: increase water permeability in the late distal tubule and collecting duct principle cells |
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Aldosterone
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Stimulus for secretion: decreased blood volume via renin- angiotensin II and also increased plasma potassium concentration.
Time Course: slow Mechanism of action: new protein synthesis Actions on Kidneys: increase sodium reabsorption in the distal tubule principal cells. increase potassium secretion in the distal tubule principle cells. increase hydrogen secretion in the distal tubule at the alpha intercalated cells |
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ANP
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Stimulus for secretion: atrial pressure
Time Course: fast Mechanism of action: guanylate cyclase, cGMP Actions on Kidneys: increase GFR, decrease sodium reabsorption |
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Angiotensin II
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Stimulus for secretion: decreased blood volume via renin
Time Course: fast Mechanism of action: Actions on Kidneys: increased sodium hydrogen exchange at the proximal tubule. increased bicarbonate reabsorption at the proximal tubule |
