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40 Cards in this Set

  • Front
  • Back
increase in total body water after osmotic equilibrium
3% sodium chloride (NaCl) solution
hypertonic, water flows out
Increases in both renal blood flow and glomerular filtration rate GFR
caused by Dilation of Afferent Arterioles
osmolarity of renal tubular fluid that flows through the early distal tubule
usually hypotonic, compared with the plasma
decrease the number of functional nephrons to 25% of normal
Decreased maximal urine concentrating ablility
decrease potassium (K+) secretion by the cortical collecting tubule
A diuretic that inhibits the action of Aldosterone
Blocking big Al Dosterone's actions will
inhibit potassium secretion
diabetes insipidus due to lack of ADH secretion
UP plasma osmolarity
UP plasma Na secretion
UP plasma renin secretion
UP urine volume
a very high plasma RENIN activity of 12 ng. angiotensin 1/ml/hr (normal=1). Diagnosis is renin-secreting tumor:
UP plasma Aldosterone
SAME Na excretion rate
DOWN plasma K+ concentration
DOWN renal blood flow`
toxin ingestion that caused impairment of PCT NaCl reabsorption?
PCT NaCl impairment: This would decrease the GFR (glomerular filtration rate)
GFR 150 ml/min
Plasma glucose 300 mg/dl
Rate of urinary glucose excretion?
GFR x plasma glucose / 100
150 x 300 = 45000/100
45000/100 = 450mg/ml FILTERED LOAD(450) - plasma glucose (300)=150mg/min
urinary glucose excretion formula:
GFR x plasma glucose/ 100
then
this answer (filtered load) - ?
plasma glucose = urinary glucose excretion
150x300/100
45000/100
450-300 = 150
increase PERITUBULAR capillary reabsorption
Increase Efferent arteriole resistance
hyperkalemia
Inhibit aldosterone with diuretic, get hyperkalemia
concentration of urea in the tubular fluid at the end of the proximal tubule?
It is higher than the concentration of urea in the plasma
Increase the GFR?
increased glomerular Capillary Filtration Coefficient
glomerulo-nephritis
Creatinine
If GFR suddenly decreases from 100 to 50, and tubular reabsorption from 99 to 50, what happens?
Urine flow rate will decrease by 50% because Urine lfow rate = GFR - tubular reabsorption rate. If GFR is 50 and t.r.r. is 50, the urine flow rate is ZERO! (50-50=0)
Hydrostatic glom cap= 50
Hydrostatic Bowmans space = 12
Colloid osmotic glom cap = 30
Net pressure driving glom filtration?
50 - (12 + 30 = 42)
50 - 42 = 8

Hydrostatic Glomerular Capillary pressure is ALONE
increase K+ secretion by cortical collecting tubule
diuretic that decreases loop of Henle's Na+ reabsorption
Dietary K+ increases, then K+ excretion balance maintained by
Increased K+ secretion by LATE DISTAL COLLECTING TUBULES
Juvenile type 1 diabetes polyuria and polydipsia occur because?
a rising glucose concentration in the proximal tubule DECREASES the osmotic driving force for water reabsorption
acidosis, most of the hydrogen ions secreted by the PCT
Reabsorption of bicarbonate ions
Phosphate filtration exceeds transport maximum for Phosphate absorption
Phosphate can contribute significantly to titratable acid i the urine
severe renal disease sinks number of functional nephrons to 25%
Increased glomerular filtration rate (GFR) of surviving nephrons
hypoATREMIA
excessive ADH excretion
diagram: lack of ADH secretion causing severe diabetes, part of tubule with lowest tubular fluid osmolarity?
E (collecting duct) HYPERNATREMIA
diagram: very low K+ diet, which part of nephron absorbs most K+?
A (PCT) because 65% of filtered K+ is reabsorbed in the PCT
diagram: Which part of nephron reabsorbs the MOST WATER?
A (PCT) at 65%

ascending loop essentially impermeable to water
diagram: lowest permeability to water during antidiureisis?
C the ascending limb THICK part, especially during antidiuresis due to ADH increase
dehyrated person
increased water permeability of COLLECTING DUCT
50% decrease in renal EFFERENT artery resistance
UP renal blood flow
DOWN glomerular filtration
DOWN glom cap hydrostatic pres.
UP peritubular cap hydro pressure
early distal tubule region of Macula densa
It is usually HYPOtonic (the diluting segment because all the ions are out)
correct statement is
Urea reabsorption in the PCT is GREATER than in the cortical collecting tubule
primary site of Mg+ reabsorption
Ascending loop of Henle for Mg+
tuboglomerular feedback requires
Signaling from the MACULA DENSA to the JG Cells
similar values for intracellular and interstitial body fluids?
TOTAL osmolarity
very high levels of Al dosterone, percentage of filtered load of Na+ reabsorbed by DCT and collecting duct?
less than 10%
true
Osmolarity of fluid in the early DCT would be less than 300 mOsm/L in a dehydrated person with normal kidneys and increased ADH levels
high Na+ diet
decreased plasma RENIN
dehydrated construction worker has a stroke
High ADH
High RENIN
High ANGIOTENSIN II
High AL DOSTERONE