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40 Cards in this Set
- Front
- Back
increase in total body water after osmotic equilibrium
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3% sodium chloride (NaCl) solution
hypertonic, water flows out |
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Increases in both renal blood flow and glomerular filtration rate GFR
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caused by Dilation of Afferent Arterioles
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osmolarity of renal tubular fluid that flows through the early distal tubule
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usually hypotonic, compared with the plasma
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decrease the number of functional nephrons to 25% of normal
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Decreased maximal urine concentrating ablility
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decrease potassium (K+) secretion by the cortical collecting tubule
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A diuretic that inhibits the action of Aldosterone
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Blocking big Al Dosterone's actions will
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inhibit potassium secretion
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diabetes insipidus due to lack of ADH secretion
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UP plasma osmolarity
UP plasma Na secretion UP plasma renin secretion UP urine volume |
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a very high plasma RENIN activity of 12 ng. angiotensin 1/ml/hr (normal=1). Diagnosis is renin-secreting tumor:
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UP plasma Aldosterone
SAME Na excretion rate DOWN plasma K+ concentration DOWN renal blood flow` |
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toxin ingestion that caused impairment of PCT NaCl reabsorption?
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PCT NaCl impairment: This would decrease the GFR (glomerular filtration rate)
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GFR 150 ml/min
Plasma glucose 300 mg/dl Rate of urinary glucose excretion? |
GFR x plasma glucose / 100
150 x 300 = 45000/100 45000/100 = 450mg/ml FILTERED LOAD(450) - plasma glucose (300)=150mg/min |
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urinary glucose excretion formula:
GFR x plasma glucose/ 100 then this answer (filtered load) - ? |
plasma glucose = urinary glucose excretion
150x300/100 45000/100 450-300 = 150 |
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increase PERITUBULAR capillary reabsorption
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Increase Efferent arteriole resistance
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hyperkalemia
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Inhibit aldosterone with diuretic, get hyperkalemia
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concentration of urea in the tubular fluid at the end of the proximal tubule?
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It is higher than the concentration of urea in the plasma
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Increase the GFR?
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increased glomerular Capillary Filtration Coefficient
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glomerulo-nephritis
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Creatinine
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If GFR suddenly decreases from 100 to 50, and tubular reabsorption from 99 to 50, what happens?
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Urine flow rate will decrease by 50% because Urine lfow rate = GFR - tubular reabsorption rate. If GFR is 50 and t.r.r. is 50, the urine flow rate is ZERO! (50-50=0)
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Hydrostatic glom cap= 50
Hydrostatic Bowmans space = 12 Colloid osmotic glom cap = 30 Net pressure driving glom filtration? |
50 - (12 + 30 = 42)
50 - 42 = 8 Hydrostatic Glomerular Capillary pressure is ALONE |
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increase K+ secretion by cortical collecting tubule
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diuretic that decreases loop of Henle's Na+ reabsorption
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Dietary K+ increases, then K+ excretion balance maintained by
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Increased K+ secretion by LATE DISTAL COLLECTING TUBULES
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Juvenile type 1 diabetes polyuria and polydipsia occur because?
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a rising glucose concentration in the proximal tubule DECREASES the osmotic driving force for water reabsorption
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acidosis, most of the hydrogen ions secreted by the PCT
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Reabsorption of bicarbonate ions
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Phosphate filtration exceeds transport maximum for Phosphate absorption
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Phosphate can contribute significantly to titratable acid i the urine
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severe renal disease sinks number of functional nephrons to 25%
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Increased glomerular filtration rate (GFR) of surviving nephrons
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hypoATREMIA
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excessive ADH excretion
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diagram: lack of ADH secretion causing severe diabetes, part of tubule with lowest tubular fluid osmolarity?
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E (collecting duct) HYPERNATREMIA
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diagram: very low K+ diet, which part of nephron absorbs most K+?
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A (PCT) because 65% of filtered K+ is reabsorbed in the PCT
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diagram: Which part of nephron reabsorbs the MOST WATER?
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A (PCT) at 65%
ascending loop essentially impermeable to water |
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diagram: lowest permeability to water during antidiureisis?
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C the ascending limb THICK part, especially during antidiuresis due to ADH increase
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dehyrated person
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increased water permeability of COLLECTING DUCT
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50% decrease in renal EFFERENT artery resistance
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UP renal blood flow
DOWN glomerular filtration DOWN glom cap hydrostatic pres. UP peritubular cap hydro pressure |
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early distal tubule region of Macula densa
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It is usually HYPOtonic (the diluting segment because all the ions are out)
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correct statement is
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Urea reabsorption in the PCT is GREATER than in the cortical collecting tubule
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primary site of Mg+ reabsorption
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Ascending loop of Henle for Mg+
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tuboglomerular feedback requires
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Signaling from the MACULA DENSA to the JG Cells
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similar values for intracellular and interstitial body fluids?
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TOTAL osmolarity
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very high levels of Al dosterone, percentage of filtered load of Na+ reabsorbed by DCT and collecting duct?
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less than 10%
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true
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Osmolarity of fluid in the early DCT would be less than 300 mOsm/L in a dehydrated person with normal kidneys and increased ADH levels
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high Na+ diet
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decreased plasma RENIN
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dehydrated construction worker has a stroke
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High ADH
High RENIN High ANGIOTENSIN II High AL DOSTERONE |