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10 Cards in this Set
- Front
- Back
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name 5 disorders involving renal failure with schistocytes
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HUS, TTP, DIC, scleroderma, malignant HTN
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in what region of the adrenal gland is aldosterone lcoated?
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zona glomerulosa, the outer most layer
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angiotensin II is broken down into what? what is this compound's purpose?
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angiotensin III, which modulates Aldosterone
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how does K+ relate to Aldo levels?
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hyperkalemia directly stimulates Aldo release
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inhibitors of Aldosterone synthesis?
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somatostatin, dopamine, heparin, ANP
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in renal vascular disease, renin must be ____ times higher in the renal vein to predict a good response to surgery?
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1.5x higher renin in affected side's vein
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what drugs are contraindicated in patients with high renin activity and renal vascular disease due to their ability to stimulate the RAAS?
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diuretics, contraceptives (estrogens), glucocorticoids
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name diseases with HTN with low renin levels
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primary aldosteronism (Conn Syndrome)
-diabetes mellitus |
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what is benign nephrosclerosis? how will it affect kidney micro and gross appearance
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-hyaline arteriolosclerosis due to HTN
-will cause thickened and narrowed BVs, leading to patchy ischemic atrophy w/ focal loss of parenchyma, giving the kidney a granular appearance |
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micro and gross appearance of kidney after malignant HTN?
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gross - "flea bitten" due to tiny hemorrhages on kidney
micro - hyperplastic arteriolosclerosis w/ onionskin thickening of arterioles (this is what leads to schistocytes!) |
