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18 Cards in this Set
- Front
- Back
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GFR as a function of filtration pressure
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GFR = Kf * MFP,
where MFP = (P-GC - P-BS) - mean COP-gc and mean COP-gc = (GOP afferent + COP efferent) / 2 |
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RPF
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RPF = RBF * (1-hematocrit)
where hematorcrit normally is .4 |
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Clearance of z
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Cz = (Uz *Vdot-z)/Pz
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filtered load of z
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FL = GFR * Pz
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Excreted load of z
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= Uz * Vdot-z
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Renal plasma flow (2) (the real one)
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RPF = Cpah / Epah
where Extraction ratio of Pah is .9, and Cpah = clearance of Pah or Upah*V/Ppah |
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RBF
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= RBF/(1-hematocrit)
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Normal plasma Na
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135-145 meq/L
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Normal K concentration in plasma
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4-5 meq/L
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Normal plasma osmolarity
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280-295
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Normal GFR
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100-120
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Normal fasting glucose
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80-100
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Transporters for Na in the proximal tubule
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APICAL:
Na/Cl cotransporter Na/glc cotransporter Na/AA cotranporter Na/H+ antiporter (affected by syp drive and Ang II) |
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Na Transporters in the ascending limb of LOH
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Na/Ca/2Cl- cotranspporter. Inhibited by Furosemide/lasix and maybe ADH
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check that:
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ADH may ENHANCE that one.
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Na transport in descending limb
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NO UPTAKE CHANNELS
but some passive leakback paracellularly |
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Na reabsorption in th eealy distal tubule
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Na/Cl cotranporter
Inhibited by Thiazide |
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Na Tranport in principal cells of DT/CT
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ENaC
turned on by aldosterone Inhibited by amiloride |
