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18 Cards in this Set

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GFR as a function of filtration pressure
GFR = Kf * MFP,

where MFP = (P-GC - P-BS) - mean COP-gc

and mean COP-gc = (GOP afferent + COP efferent) / 2
RPF
RPF = RBF * (1-hematocrit)

where hematorcrit normally is .4
Clearance of z
Cz = (Uz *Vdot-z)/Pz
filtered load of z
FL = GFR * Pz
Excreted load of z
= Uz * Vdot-z
Renal plasma flow (2) (the real one)
RPF = Cpah / Epah

where Extraction ratio of Pah is .9, and Cpah = clearance of Pah or Upah*V/Ppah
RBF
= RBF/(1-hematocrit)
Normal plasma Na
135-145 meq/L
Normal K concentration in plasma
4-5 meq/L
Normal plasma osmolarity
280-295
Normal GFR
100-120
Normal fasting glucose
80-100
Transporters for Na in the proximal tubule
APICAL:
Na/Cl cotransporter
Na/glc cotransporter
Na/AA cotranporter
Na/H+ antiporter (affected by syp drive and Ang II)
Na Transporters in the ascending limb of LOH
Na/Ca/2Cl- cotranspporter. Inhibited by Furosemide/lasix and maybe ADH
check that:
ADH may ENHANCE that one.
Na transport in descending limb
NO UPTAKE CHANNELS

but some passive leakback paracellularly
Na reabsorption in th eealy distal tubule
Na/Cl cotranporter
Inhibited by Thiazide
Na Tranport in principal cells of DT/CT
ENaC
turned on by aldosterone
Inhibited by amiloride