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4 Cards in this Set
- Front
- Back
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Class of diuretic
Carbonic anhydrase inhibitors acetazolamide |
Site of action: proximal tubule
Mechanism: inhibition of carbonic anhydrase Major Effects: increase bicarbonate exretion |
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Class of diuretic
Loop Diuretics furosemide ethacrynic acid bumetanide |
Site of action: thick ascending limb of the loop of henle
Mechanism: inibition of Na-K 2 Cl triple cotransporter Major Effects: increase NaCL exretion, increased potassium excretion via an increase in the distal tubule flow rate. increased calcium excreation- used to treat hypercalcemia. decreased abiity to concentrate urine via a decrease in the corticopapillary gradient. decreased ability to dilute urine via inhibition of the diluting segment |
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Class of diuretic
Thiazide diuretics chlorthiazide, hydrochlorothiazide |
Site of action: early distal tubule (cortical diluting segment)
Mechanism: inhibition of Na-Cl cotransport Major Effects: increased NaCL excretion, increased potassium excretion via increased distal tubule flow rate. decreased calcium excretion- a treatment of idiopathic hypercalciuria. decreased ability to dilute urine via inhibitiong of the cortical diluting segment. no effect on the ability to concentrate the urine however. |
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Class of diuretic
K sparing diruetics spironolactone triamterene amiloride |
Site of action: late distal tubule and collecting duct
Mechanism: inhibition of sodium reabsorption, inhibition of potassium secretion. inhibit hydregen ion secretion. Major Effects: increased sodium excretion- a small effect. decreased potassium excretion- use thiazide or loop diuretics in combination to mitigate the negative effects of this. decreases hydrogen excretion. |
