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87 Cards in this Set

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What is the osmolarity of NS, LR,

Isotonic

What is the osmolarity of 3%NS, D5W 1/2NS, D5W LR?

Hypertonic

What is the osmolarity 1/2 NS and D5W


1/2 NS and D5W

Hypotonic

What is the normal range of serum osmolarity?tt

280-300 mOsm/kg

What condition does normal saline causes?

Hyperclorimic acidosis, which is associated with AKI and Inc mortality

What does the patient's osmolality tell you?

Whether they are dehydrated, has excess water in serum or have access or deficiency in sodium, glucose and urea

What is the normal range of serium sodium?

135-145

Associated with briard range of neurological manifestation

Hyponatremia

Hyponatremia diagnostic labs

BMP, serum osmolality, plasma osmolality, triglycerides, TSH, urine sodium, urine osmolality

Isotonic hyponatremia

Lab error-toomuch protein or triglyceride

Hypertonic hyponatremia

Hyperglycemia, mannitol, sorbitol, glycerol, Maltese and radioconstrast agents

Treatment for hypertonic hyponatremia?

Trest the underlying issue ( give fluid, insulin in DKA pts)

Pts comes into the hospital with diabetic ketoacidosis. You check a blood sugar and it come back 600, and the sodium BMP comes back at 126

Hypertonic hyponatremia

How do you treat-give insulin

Hypotonic hyponatremia hypervolemic

Congestive HF, liver disease, Arenal failure

Hypotonic hyponatremia hypovolemic

Dehydration, vomit, diarrhea, sweat and renal salt loss (diuretics, ace inhibitors, nephropathy, sodium wasting syndrome, mineralocorticoid deficiency)

Low urine sodium concentration <10-20 meq/L

Nonmetallic cause- dehydration, vomiting, diarrhea and sweat

High urine sodium >20 meq/L

Renal cause ( diuretic mc thiazides, Ace inhibitors)

Euvolemic hypotonic hyponatremia

Problem with ADH ( SIADH) MC

Inc. ADH ( inappropriately concentrated urine >100

MC cause is SIADH, hypothyroidism, postoperative hyponatremia

Decreased ADH (diluted urine with urine osmolality <100

MC Primary polydipsia. Beer potomania (alcohol inhibits ADH)

Treatment for hypotonic hyponatremia

Acutely-hypertonic saline (3%NS)


Chronic-sodium chloride tablets and fluid restriction, NS

Fast rate correction can lead to what condition?

Osmotic demyelination syndrome (ODS)

What labs do you want for hypernatremia?

BMP, serum osmolality, urine osmolality and urine electrolytes

Hypernatremia

Too much salt, diabetes insipid, mineralocorticois excess ( hyperaldosteroism, Cushing disease)

Treatment for hypernatremia

Goal is to replace free water deficit ( isotonic fluid)

Normal potassium range?

3.5-5 meq/L

What are the most common way to lose potassium (hypokalemia)?

1. Not enough intake (alcoholic patient), or too much loss through kidney and gut


2.K+ shift from blood to cells


3. Hyperalosteronism (rare)

What cause K+ to shift from blood to cells

Insulin, beta adrenergic activity, alkalosis, Elevated PH in the cells

What are drugs that inc K+ excretion?

Steroid, diuretic

Drugs that push K+ into the cells?

Insulin administration and beta agonist (IV or nebulized)

What are the causes of hyperkalemia?

Inc K+ release from cells, renal impairment, medication


( insulin deficiency, beta blockers, metabolic or respiratory acidosis)

Seroius manifestation of hyperkalemia

>7meq/L. Muscle weakness of paralysis, cardiac manifestation, reduced urinary acid excretion-metabiloc acidosis

Hyperkalemia treatment?

IV calcium gluconate ( stabilize ecg), insulin and beta agonist, diuretics and prevention

Ekg findings in hypokalemia

St segment depression, flattened T wave and U wave

Ekg finding in hyperkalemia

Peaked T wave, prolong PR intervals, ST depression, widened QRS

Normal calcium

8.5-10.5

Hypercalcemia cause

Malignancy and hyperparathyroidism

Hypercalcemia symptoms

Bones, stones, groans (constipation), moans (peptic ulcer, pancreatitis)pancreatic, overtones ( depression, confusion)

Hypercalcemia treatment

Isotonic saline, IV loop diuretics,


Calcitonjn, IV bisphosphonates (in cancer pts), glucocorticoids

Causes of hypocalcemia

Low PTH, vitamin D deficiency, low magnesium, tissue consumption of calcium

Hypocalcemia manifestation

Tetanus, papilledema, and seizures

Treatment for hypocalcemia

Iv or oral calcium

Treatment for hypophosphatemia

Milk or oral phosphorous ( can jnduce diarrhea)

Causes of hypophosphatemia

Dec intake, inc renal wasting, fluid shift from cells to blood

Treatment for hyperphosphatemia

Restrict dietary intake, phosphate binders, inc dialysis

Normal phosphate

4.5

CKD definition

-presence of kidney damage for 3 months: albuminuria= ACR >30, abnormalities, kidney transplant


-GFR <60


Acute prostatitis treatment for non sexual active men

Bacterium or fluoroquinolone for 4-6 weeks

Acute prostatitis for sexual active men

Cetriaxone and doxy for 4-6 weeks

Firm and tender prostate, constitutional symtoms

Acute bacterial prostatitis

Painless hematuria, urothelial carcinoma, cigarette smoking MC risk factor

Bladder cancer

Renal cell carcinoma triad

Flank pain, hematuria, palpable abdominal renal mass

Gleason is a 60 year old AA men who present with back pain, LUTS. What is the lost likely dx?

Prostate cancer

Flank pain radiating to groin, patient can't lie still, hematuria, noncontract CT is definitive dx

Nephrolithiasis


<5mm pass, >5 (medication tamsulosin), >10 urology consult

Calcium oxalate MC


Struvite-proteus infection


Uric acid- gout and radiolucent xray


Cistine-FH

Painless swelling of the testicle, crytochidism MC risk factor


Labs: elevated beta hcg, AFP or LDH

Testicular cancer

Dilated and tortuous veins of the scrotum, heavy sensation, swelling decrease with supine position. left side>right. Infertility

Varicocele

Bag of worm

Abdominal, flank and back pain, hematuria, bilateral enlarged kidney, autosomal dominant

Polycystic kidney disease

Tx: BP control, hydration, sodium restriction diet, Tolvaptan

Peritoneal fluid, translluminates, painless, children, increase in size with Valhalla maneuver

Hydrocele

WBC cast

Pyelonephritis, interstitial nephritis

RBC cast

Glomerulonephritis

Fatty cast

Nephrotic syndrome, minimal change syndrome

Muddy brown casts

Acute Tubularnephritis

Renal stenosis

Inc aldosterone, ADH and angiotensin

Abdominal bruit, refractory hypertension

Renal stenosis

Low C3 comp, cola color urine, post strep/impetigo,

PSGN

Positive ASO titer, supportive care

E coli 0157h7, shiga toxin, bloody diarrhea, petechial rash, thrombocytopenia

Hus

School age

Chronic sinusitis, saddle deformity, skin rash,

Wegners

+C-ANCA

Good pastures

Anti GBM, hemoptysis, hematuria, steroid

Gross hematuria, post URI or GI, young men

IgA

Control bp

Acute prostatitis risk factors

Catheters, instrumentation, prostate bx

Tx for 6 weeks

Twist score for torsion

Hard testis, swelling testis, negative crematorium reflex, high riding testis, N/V

Mc acite scrotal pain in Prepubescent boys, blue dot spot, supportive care

Appendix torsion

Failure to produce ADH, resulting in inc extracellular fluid osmolaity-> vasopresin challenge Dec urine volume and Inc urine osmolality

Central diabetes insipidus

High ADH, no change in using volume or osmolality

Nephrogenic diabetes insipidus

Drug: lithium, demeclocycline, amphotericin B

MC inherited cause of kidney disease, mutation in pkd1

Polycystic kidney disiease

When to dialyse

Acidosis, electrolytes, ingestion (SLIME), overload, uremia, gfr<15

Cause of anion gab metabolic acidosis

Cardia output, Methanol, Uremix, Dka, Ethylene glycol, Salicylate (asapirin),

SIADH

Hyponatremia

Trousseau, chvostek sign

Hypocalcemia

Hyperparathyroid, malignancy

Hypercalcemia

Treatment for hyperkalemia

Insulin, Calcium, Bicarbonate,


Kayexalate, xation exchange resins

Inulin, urea, glucose, acid and K+

Filtration only, filtration and partial reabsorption, filtration ND complete reabsorption, filtration and secretion

Mc solid tumor in men 15-35

Testicular cancer

Hydronephrosis on US

Kidney stones

AKI pre renal cause and values

Dehydration and hypoperfususion


Bun/Cr=20:1


U NA= <20


FeNA= <1


SG= >1.010

High urine osmolality

AKI renal cause and values

Glomerular, tubular and interstitial


Bun/Cr = 15:1


U NA >40


FeNA <2


SG normal


Urine osmolality is low