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23 Cards in this Set
- Front
- Back
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1. What is the relationship between renal oxygen consumption and Na reabsorption?
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a. Positively linear
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2. What is the principal primary active transport system in the kidney?
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a. Na/K ATPase
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3. What is the Na/K ratio in Na/K ATPase?
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a. 3 Na out
b. 2 K in |
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4. What is the arrangement of the glomerular and peritubular capillaries?
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a. Series
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5. What is the function of glomerular capillaries?
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a. Filtration
b. Capillary pressure > oncotic pressure |
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6. What is the function of peritubular capillaries?
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a. Reabsorption of fluid
b. Oncotic pressure > hydrostatic pressure |
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7. What is the purpose of autoregulation of RBF and GFR?
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a. Maintain constancy of glomerular filtration over a wide range of perfusion pressures
b. Uncouples renal function from changes in arterial pressure and ensures maintenance of renal function |
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8. What is pressure diuresis?
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a. Urine output increases dramatically with an increase in arterial pressure
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9. When does myogenic constriction occur in the kidneys?
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a. In response to sudden increases in renal perfusion pressure
b. Increase in pressure stretches the arteriole→ vasoconstriction c. Blood flow and hydrostatic pressure reduced |
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10. Upon what is autoregulation of GFR dependent?
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a. Autoregulation of renal blood flow
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11. What is the role of the macula densa in tubuloglomerular feedback?
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a. Sense changes in flow and solute delivery
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12. What is tubuloglomerular feedback?
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a. If GFR is too high such that it exceeds the ability of the nephron to adequately reabsorb water and solutes, the increased flow and Cl results in vasoconstriction of the afferent arteriole to decrease RBF and GFR
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13. What happens to renin release in a high GFR?
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a. Inhibited via ATP
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14. What leads to renin release during a high GFR?
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a. PGE2
b. NO |
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15. What is the level of sympathetic tone in the kidney?
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a. Low
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16. What does low level stimulation of afferent and efferent arterioles cause?
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a. Constriction
b. Less of a decrease in GFR than RBF |
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17. What does higher stimulation of the afferent and efferent arterioles cause?
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a. Parallel reductions in RBF and GFR
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18. What does extrinsic control influence?
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a. Maintenance of arterial pressure
b. NOT the preservation of renal function |
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19. What is the role of prostaglandins in the kidney?
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a. Antagonize the constrictor effects of sympathetic stimulation and angiotensin II
b. Prevent excessive vasoconstriction that might reduce renal blood flow too much (ischemia) |
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20. What do ANP and urodilatin cuase?
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a. Renal vasodilation
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21. What can extended use of indomethacin and other NSAIDs in hypovolemic states lead to?
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a. Intense renal vasoconstriction
b. Ischemia c. Renal damage/failure |
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22. What is the limiting element in glomerular filtration?
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a. Basement membrane pores
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23. What is the function of mesangial cells?
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a. Contractile
b. Modify size of slit diaphragm between podocytes |
