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16 Cards in this Set

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What is the problem w/ folate as ingested from dietary sources?
It has lots of extra glutamate residues so can not be absorbed
How is the folate problem fixed?
Conjugase enzyme cleaves the extra glutamate residues
What is the role of dihydrofolate reductase
reduces folate to dihydrofolate then tetrahydrofolate
What is methotrexate?
inhibitor of DHFR
How do sulfa drugs work?
inhibit bacterial folate biosynthesis
What does N5-N10 methylene tetrahydrofolate do?
Holds onto methyl group
What happens when serine reacts with tetrahydrofolate?
Serine rids itself of methyl group which forms N5N10 methylene tetrahydrofolate and turns into glycine
What happens to glycine when it reacts with tetrahydrofoalte
CO2 and NH4 are given off and N5-N10 methylene tetrahydrofolate is formed
How is N5 methyl tetrahydrofolate formed?
reduction of N5N10 methylene tetrahydrofolate
What is N5 methyltetrahydrofolate used for?
in the biosynthesis of methionine by having homocysteine acquire a methyl
How is N10 formyl tetrahydrofolate formed?
oxidation and addition of H20 to methylene tetrahydrofolate
What is used in the biosynthesis of methionine?
N5 methyl THF (donates a methyl group)
vitamin B12
homocysteine
How is adomet formed?
breakdown of ATP donates the adenine to methionine to form adomet
What is the role of SAM
SAM is a biological methylator and donates a methyl group to norEpi to form Epi. ALso in DNA methylation
HOw do you get from THF to N5 methyl THF
a carbon donor such as serine or glycine is used to form N5N10 methylene THF. This is then reduced to form N5 THF
What is a common symptom of a folate deficiency?
megaloblastic anemia w/ appearance of large immature erythrocytes (megaloblasts) in blood