Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
37 Cards in this Set
- Front
- Back
IF and EM: “ribbon-like” zone of increased density within the GBM and mesangial matrix
associated with? |
Type II MPGN: dense deposit disease
|
|
proliferations of the pariatal glomerulous are known as crescents... what is this seen in?
|
Type II MPGN: Dense Deposit Disease
also type I, RPGN, and Anti-GBM |
|
In Type II MPGN: Dense Deposit Disease, what antibody to what complement protein is typical for membranoproliferative glomerulonephritis.
|
C3
can help distinguish Type II from type I MPGN |
|
Lupus is what kind of disease? What is the one of the more common features?
|
Autoimmune
Nephritis |
|
in SLE ______ form to in situ antigens or circulating antigens; deposit in variety of glomerular locations
|
Immune complexes
|
|
what is a treatment for Lupus?
|
immunosupression (corticosteroids)
|
|
wire loop histo appearance =
|
Lupus
|
|
Most common form of GN in the world
? |
IgA Nephropathy (Berger Disease)
|
|
who is most affected by IgA Nephropathy (Berger Disease)
|
young men
|
|
to be nephrotic, what criteria has to be met?
|
>3.5 grams protein in urine per 24 hours
|
|
Deposition of IgA-dominant immune complexes, with high levels of circulating IgA
|
IgA Nephropathy (Berger Disease)
|
|
in IgA Nephropathy (Berger Disease), where is IgA deposited
|
the mesangium
|
|
What is Goodpasture's disease? what is one of the problems normally seen in this?
|
Kidney + pulmonary disease
kidney problem is Anti-GBM GN |
|
what do you treat Goodpasture's with?
|
high-dose immunosuppressants
|
|
what does Anti-GBM GN often follow?
|
URI
|
|
what happens in Anti-GBM GN
|
Autoantibody directed against portion of type IV collagen molecule present in GBM
|
|
what will be your major LM finding of Anti-GBM GN
|
glomerular crescents >90%... feature of rapidly progressive glomerulonephritis
|
|
if you see IF findings of diffuse linear staining of GBM for IgG what do you likely have?
|
Anti-GBM GN
|
|
what is the hallmark of Rapidly Progressive GN (RPGN)
|
Crescents on light microscopy
|
|
what are the 3 types of Rapidly Progressive GN (RPGN)
|
TYPE I (ANTI-GBM ANTIBODY)
---Goodpastures TYPE II (Immune complex) --Lupus --IgA nephropathy (Henoch-Schonlein purpura) TYPE II (Pauci-immune) |
|
pts with Hereditary Nephridites present with?
|
hematuria
|
|
what are the 2 types of Hereditary Nephridites
|
Thin basement membrane disease
Alport syndrome |
|
what is the most common cause of Hereditary Nephridites
|
thin membrane disease
this is usually asymptomatic |
|
in Hereditary Nephridites, you have mutations in genes coding for alpha chains of ______
|
type IV collagen
|
|
EM shows what in Hereditary Nephridites
|
thinning of the GBM
|
|
pt has hematuria with progression to CRF (also nerve deafness, eye disorders)
|
Alport syndrome
|
|
what is the genetics underlying Alport syndrome
|
Majority are X-linked (males express full form; females limited to benign hematuria)
Defective assembly of collagen type IV (GBM, BM of eye lens, cochlea) |
|
the EM finding of alternating thinning and thickening of GBM is seen in
|
Alport syndrome
|
|
Progressive renal failure
Oliguria, proteinuria, edema, azotemia, uremia, death Anemia (deficient EPO), anorexia, general malaise Most patients are hypertensive with cardiac and CNS effects clinical symptoms of? |
Chronic Glomerulosclerosis (CGN)
|
|
ppl who survive acute phase of RPGN generally develop....
|
Chronic Glomerulosclerosis (CGN)
|
|
Shrunken kidney with diffuse granular cortical surface is descriptive of?
|
Chronic Glomerulosclerosis (CGN)
|
|
arteriolar sclerosis, tubular atrophy, renal osteodystrophy are signs of?
|
Chronic Glomerulosclerosis (CGN)
|
|
12 yr old presents with periorbital, abdominal, and ankle swelling. She had been in good health until several months ago when she gained some weight and noted swelling in her legs. A Chest xray shows bilateral pleural effusions without evidence or lung disease. a urinalysis reveals heavy proteiunuria (8kg/24hr) there is no hematuria. a percutaneous needle biospy of the kidney reveals no morphological abnormality via LM. which of the following best describes the most likely medical condition responsible:
Amyloid nephropathy Focal segmental glomerulosclerosis Hereditary nephritis Membranous glomerulophay Minimal change disease |
her lipids would probably be?
high, and found in urine answer: Minimal change disease |
|
2 conditions associated with amyloid nephrophathy
|
multiple myeloma (AL)
Chronic inflammatory process (AA) ---think auto immune causing this |
|
Focal segmental glomerulosclerosis
|
African American adult
|
|
An 8 year old girl presents with headaches dizziness and malaise. PE shows edema. Her PB is 180/110 and 24 hr urine reveals oliguria, hematuria, and 2.7g protein. A kidney biopsy shows electron-dense sub-epithelial humps. What would be the most likely additional finding in this girl:
Kidney biopsy with no appreciable findings by LM and IF Bilateral nerve deafness serology positive for nephritic factor a history of antecedent pharyngitis progression to chronic renal failure despite aggressive corticosteroid therapy |
she probably has: Post infectious glomerulonephritis
Answer: a history of antecedent pharyngitis a) associated with: minimal change disease or focal segmental glomerular sclerosis (FSGS)---not correct b)Alports syndrome (x linked recessive, if a girl has it, it would be benign) |
|
EM finding of minimal change disease?
|
podocyte foot process effacement
|