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30 Cards in this Set
- Front
- Back
- 3rd side (hint)
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hartnups
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def of neutral amino acid transporter in PCT (tryptophan)
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-->pellagra
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post-strep GN
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subepi IC humps, granular IF
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peripheral and periorbital edema
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diffuse proliferative GN
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subendo ICs, granular IF
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can be nephrotic
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Berger's dz
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IgA
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after URI or GI
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Alport's
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type IV collagen mutation, split basement membrane
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nerve disorders, ocular disorders, deafness, XLD
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nephrotic
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proteinuria, hyperlipidemia, fatty casts, edema, thromboembolism, incr risk of ifxn due to loss of Igs
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membranous GN
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diffuse capillary and GBM thickening, spike and dome appearance with subepi deposits. granular IF
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from drugs, ifxns, SLE, solid tumors. most common cause of adult nephrotic stnd
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memranoproliferative GN
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subendo ICs with granular IF. type I tram-track d/t GBM splitting
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assoc with hep
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ammonium magnesium phosphates stones
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caused by ifxn with urease-positive bugs. staghorn. worse with alkauria
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cystine stones
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treat with alkalinization of urine
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Wilm's tumor
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deletion of WT1 tumor suppressor gene on Ch11. WAGR: wilms, aniridia, genitourinary malformation, retardation
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transitional cell cancer risk factors
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phenacetin, smokine, aniline dyes, cyclophosphamide
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pyelonephritis lab signs
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white cell casts
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drug-induced interstitial nephritis
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diuretics, NSAIDS, PCN, sulfa, rifampin
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diffuse cortical necrosis
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vasospasm, DIC, abruptio placentae, septic shock
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ATN
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granular casts from ischemia, crush injury, toxins
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renal papillary necrosis
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assoc with DM, acute pyelo, phenacetin, sickle cell
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pre-renal azotemia
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decr GFR, Na and urea retained so BUN/creatinine incr
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intrinsic renal AKI
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from ATN often, RPGN. decr GFR. BUN resorp impaired so decr BUN/creatinine
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renal failure s/sx
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edema, hyperkalemia, acidosis, uremia (N, anorexia, pericarditis, asterixis, encephalopathy, platelet dysfxn), anemia, 2 hyperPTH, dyslipidemia, growth retard
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ADPKD
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AD. assoc with berry aneurysms, liver cysts, MVP
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ARPKD
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hepatic fibrosis, Potters in utero, HTN, portal HTN, renal insufficiency
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medullary cystic dz
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fibrosis, concentrating defects. poor prog
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mannitol
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use: shock, drug OD, incr ICP
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tox: pulm edema, dehydration. contra in anuria, CHF
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acetazolamide
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use: glaucoma, urinary alkalinization, metab alkalosis, altitude sickness
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tox: hyperchloremic metab acidosis, neuropathy, NH3 tox, sulfa allergy
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furosemide
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prevents concentration of urine
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tox: ototox, hypokal, dehydr, allergy (sulfa), nephritis, gout OH DANG!
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ethacrynic acid
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use: when sulfa allergy
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tox: sim to lasix, for hyperuricemia
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HCTZ
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reduces diluting capacity.
use: NDI |
tox: hypokalemic metab acid, hyponatremia, hyperglycemia, hyperlipidemia, hyperuricemia, hypercalcemia
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K+ sparing diuretics
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spironolactone, triamterene, amiloride, eplerenone.
T&A block Na channels in CCT. |
use: hyperaldosterone, K+ deplete, CHF
tox: hyperK, gynecomastia for spirono |
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ACE inhibitor tox
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Cough, Angioedema, Proteinuria, Taste changes, hypOtension, Pregnancy probs, Rash, Increased renin, Lower ATII. CAPTOPRIL. also hyperkalemia.
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contra if bilat renal artery stenosis
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