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66 Cards in this Set

  • Front
  • Back
DOC for osteoporosis
bisphosphonates
how is duchennes muscular dystrophy inherited
X linked
what proteins are involved in non epithelial edhesions
ICAM
Selectins
integrins
cadherins
what class of diuretics inhibits Na/2Cl/K
loops
what determines how much water is reabsorbed in the distal tubules and collecting ducts
ADH
what class of diuretics affects the principle cells
k sparing
what diuretics antagonize aldosterones actions
spironolactone

eplerinone
segment of renal tubule a/w:
reabsorbs 67%
PCT
segment of renal tubule a/w:
concentrates urine
collecting ducts
segment of renal tubule a/w:
secretes organic anions and cations
PCT
segment of renal tubule a/w:
impermeable to water
thick ascending
segment of renal tubule a/w:
permeable to water only in the presence of ADH
late DCT

collecting ducts
segment of renal tubule a/w:
Na/2Cl/K cotransporter
thick ascending
segment of renal tubule a/w:
glucose and AA reabsorption
PCT
segment of renal tubule a/w:
dilutes urine
thick ascending
segment of renal tubule a/w:
isotonic fluid reabsoprtion
PCT
two main types of cells in the collecting ducts
principle

intercalated
what cells and effects does aldosterone act on
intercalated
-a=acid secretion

principle
-Na rabsorption
-K excretion
diuretic used in:
pulmonary edema
loop
diuretic used in:
hypercalciuria
thiazide
diuretic used in:
glaucoma
mannitol

acetozolamide
diuretic used in:
moderate CHF with ECV expansion
thiazide

loops
diuretic used in:
used to retain K
K sparing
diuretic used in:
edema a/w nephrotic syndrome
loop
diuretic used in:
increase IC pressure
mannitol
diuretic used in:
mild to moderate HTN
thiazide
diuretic used in:
hypercalcemia
loops
diuretic used in:
altitude sickness
acetozolamide
diuretic used in:
hyperaldosterone
spironolactone

eplerenone
site of action of mannitol
PCT
site of action of thiazides
DCT
diuretic used in px with sulfa allergy
ethycrinic acid
function of:
principle cells
reabsorb Na (H2O)

secrete K
function of:
a intercalated cell
secrete H
function of:
B intercalated cells
secrete HCO3
which part of the nephron has the lowest pH
late DCT and collecting tubules
what decreases in concentration along the proximal tubule
glucose

AA

HCO3
what increases in concentration along the proximal tubule
urea

Cl
what stays the same concentration along the proximal tubule
K

Na
what increases the most in concentration along the proximal tubule
PAH
Site of action of:
mannitol
PCT
Site of action of:
acetozolamide
PCT
Site of action of:
loops
Loop
-thick ascending limb
Site of action of:
thiazides
DCT
Site of action of:
K sparing
CCT
which diuretics increase urine NaCl levels
all
which diuretics increase urine K
all except K sparing
which diuretics lower blood pH
acetozolamide
which diuretics increase pH
loops

thiazides
MOA of:
mannitol
osmotic diuretic
MOA of:
acetozolamide
CA inhibitor
MOA of:
loops
inhibit Na/2Cl/K
-thick ascending limb
MOA of:
thiazide
inhibits Na/Cl
-early DCT
MOA of:
spironolacton/eplerinone
aldosterone receptor blocker
-CCT
MOA of:
triamterene/amiloride
block Na channels
-CCT
SE of thiazides
hyperGLUC
-glycemia
-lipidemia
-uricemia
-calcium

Hypo
-natremia
-kalemia
SE of loops
Interstitial nephritis
Gout
Ototoxicity
how do loops increase GFR
increase prostaglandin release
SE of K sparing diuretics
hyperkalemia
-arrhythmias
which drug inhibits renin
aliskiren
MOA of:
aliskiren
renin inhibitor
what kind of effect do acetozolamide have of pH
hyperchloremic met acid
what is condition is mannitol CI in
anuria

CHF
which diuretic increases serum osmolarity
mannitol
diuretic used in px with sulfa allergy
ethacrynic acid
what drugs cause sulfa allergy
celecoxib

probenecid

diuretics
-thiazides
-loops
-acetozolamide

sulfa drugs