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66 Cards in this Set
- Front
- Back
DOC for osteoporosis
|
bisphosphonates
|
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how is duchennes muscular dystrophy inherited
|
X linked
|
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what proteins are involved in non epithelial edhesions
|
ICAM
Selectins integrins cadherins |
|
what class of diuretics inhibits Na/2Cl/K
|
loops
|
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what determines how much water is reabsorbed in the distal tubules and collecting ducts
|
ADH
|
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what class of diuretics affects the principle cells
|
k sparing
|
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what diuretics antagonize aldosterones actions
|
spironolactone
eplerinone |
|
segment of renal tubule a/w:
reabsorbs 67% |
PCT
|
|
segment of renal tubule a/w:
concentrates urine |
collecting ducts
|
|
segment of renal tubule a/w:
secretes organic anions and cations |
PCT
|
|
segment of renal tubule a/w:
impermeable to water |
thick ascending
|
|
segment of renal tubule a/w:
permeable to water only in the presence of ADH |
late DCT
collecting ducts |
|
segment of renal tubule a/w:
Na/2Cl/K cotransporter |
thick ascending
|
|
segment of renal tubule a/w:
glucose and AA reabsorption |
PCT
|
|
segment of renal tubule a/w:
dilutes urine |
thick ascending
|
|
segment of renal tubule a/w:
isotonic fluid reabsoprtion |
PCT
|
|
two main types of cells in the collecting ducts
|
principle
intercalated |
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what cells and effects does aldosterone act on
|
intercalated
-a=acid secretion principle -Na rabsorption -K excretion |
|
diuretic used in:
pulmonary edema |
loop
|
|
diuretic used in:
hypercalciuria |
thiazide
|
|
diuretic used in:
glaucoma |
mannitol
acetozolamide |
|
diuretic used in:
moderate CHF with ECV expansion |
thiazide
loops |
|
diuretic used in:
used to retain K |
K sparing
|
|
diuretic used in:
edema a/w nephrotic syndrome |
loop
|
|
diuretic used in:
increase IC pressure |
mannitol
|
|
diuretic used in:
mild to moderate HTN |
thiazide
|
|
diuretic used in:
hypercalcemia |
loops
|
|
diuretic used in:
altitude sickness |
acetozolamide
|
|
diuretic used in:
hyperaldosterone |
spironolactone
eplerenone |
|
site of action of mannitol
|
PCT
|
|
site of action of thiazides
|
DCT
|
|
diuretic used in px with sulfa allergy
|
ethycrinic acid
|
|
function of:
principle cells |
reabsorb Na (H2O)
secrete K |
|
function of:
a intercalated cell |
secrete H
|
|
function of:
B intercalated cells |
secrete HCO3
|
|
which part of the nephron has the lowest pH
|
late DCT and collecting tubules
|
|
what decreases in concentration along the proximal tubule
|
glucose
AA HCO3 |
|
what increases in concentration along the proximal tubule
|
urea
Cl |
|
what stays the same concentration along the proximal tubule
|
K
Na |
|
what increases the most in concentration along the proximal tubule
|
PAH
|
|
Site of action of:
mannitol |
PCT
|
|
Site of action of:
acetozolamide |
PCT
|
|
Site of action of:
loops |
Loop
-thick ascending limb |
|
Site of action of:
thiazides |
DCT
|
|
Site of action of:
K sparing |
CCT
|
|
which diuretics increase urine NaCl levels
|
all
|
|
which diuretics increase urine K
|
all except K sparing
|
|
which diuretics lower blood pH
|
acetozolamide
|
|
which diuretics increase pH
|
loops
thiazides |
|
MOA of:
mannitol |
osmotic diuretic
|
|
MOA of:
acetozolamide |
CA inhibitor
|
|
MOA of:
loops |
inhibit Na/2Cl/K
-thick ascending limb |
|
MOA of:
thiazide |
inhibits Na/Cl
-early DCT |
|
MOA of:
spironolacton/eplerinone |
aldosterone receptor blocker
-CCT |
|
MOA of:
triamterene/amiloride |
block Na channels
-CCT |
|
SE of thiazides
|
hyperGLUC
-glycemia -lipidemia -uricemia -calcium Hypo -natremia -kalemia |
|
SE of loops
|
Interstitial nephritis
Gout Ototoxicity |
|
how do loops increase GFR
|
increase prostaglandin release
|
|
SE of K sparing diuretics
|
hyperkalemia
-arrhythmias |
|
which drug inhibits renin
|
aliskiren
|
|
MOA of:
aliskiren |
renin inhibitor
|
|
what kind of effect do acetozolamide have of pH
|
hyperchloremic met acid
|
|
what is condition is mannitol CI in
|
anuria
CHF |
|
which diuretic increases serum osmolarity
|
mannitol
|
|
diuretic used in px with sulfa allergy
|
ethacrynic acid
|
|
what drugs cause sulfa allergy
|
celecoxib
probenecid diuretics -thiazides -loops -acetozolamide sulfa drugs |