Renal: 13. Dickinson: Nephrotic Versus Nephritic Syndrome

Front 1

what are the 2 ways that immune complexes can be formed?

Back 1

in situ

pre-formed (elsewhere and gets transferred to the kidney)

Front 2

autoantibodies directed against the podocytes

exogenous antigens that are filtered into the kidney and that are trapped...then an antibody finds its way to the kidney


these are examples of what type of immune complex formation

Back 2

in situ

Front 3

where are pre-formed immune complexes normally found in the kidney?

Back 3

Subendothelial and mesangial IC deposits

Front 4

DNA-IgG complexes (lupus) and
SLO-IgG complexes (post-group A Strep infection)

are examples of what type of immune complex formation

Back 4

Pre-formed immune complexes

Front 5

if you have an inflammatory process of kidney damage, what kind of syndrome do you have? what is responsible for recruiting the neutrophils etc for this inflammation?

Back 5

inflammation = nephritic

C3a and C5 (chemoattractants)

Front 6

the mesangium and subendothelial space is where which type of syndrome occurs?

Back 6

nephritic

Front 7

the subepithelial space is where what type of syndrome occurs

Back 7

nephrotic

Front 8

the classical complement pathway utilizes what pathway (just know the basics)

Back 8

you end up producing C3 which then recruits neutrophils and other inflammatory cells

Front 9

Neutrophils do not cross GBM because complement is activated across the GBM which is not in contact with circulating inflammatory cells =

Back 9

nephrotic syndrome

Front 10

Post-streptococcal glomerulonephritis is what type of problem

Back 10

since you get immune complex in the mesangial and subendothelial space, this is nephritic

Front 11

Nephritic/Nephrotic:

Goodpasteur syndrome

Back 11

antibodies to GBM formed in situ

nephritic

Front 12

Nephritic/Nephrotic:

Systemic lupus erythematosis (SLE):

Back 12

anti-nuclear antibodies (DNA, nucleosomes) deposit in the subendothelium

nephritic

Front 13

Nephritic/Nephrotic:

Berger’s disease (IgA nephropathy)

Back 13

IgA immune complexes deposit in the mesangium

nephritic

Front 14

Nephritic/Nephrotic:

Minimal change disease

Back 14

: damage to podocytes and polyanion loss from the GBM resulting in protein loss

Nephrotic

Front 15

Nephritic/Nephrotic:

Membranous glomerulonephritis

Back 15

: can be caused by SLE anti-nuclear antibodies (DNA, nucleosomes) that deposit in the subepithelium

Nephrotic

Front 16

Nephritic/Nephrotic:

Diabetic glomerulonephritis

Back 16

non-enzymatic glycation of GBM results in high permeability and thickening

Nephrotic

Front 17

where does IgA get depositied in Berger's disease

Back 17

mesangium