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23 Cards in this Set
- Front
- Back
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First line for TB
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isoniazid (INH), Rifampin (RIF), Ethambutol (EMB), Pyrazinamide (PYZ)
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second line for TB with Renal & 8th cranial nerve AE
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Amikacin, streptomycin, kanamycin, capreomycin
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second line for TB with Static & hepatic & endocrine Aes
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ethionamide
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isoniazid (INH) dosing
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5-10mg/kg/day or 15 mg/kg 2x/week (usual 300mg with max of 900mg 2x/wk)
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isoniazid issue
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slow or fast metabolizers not checked for dosing (but can be three fold different)
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isoniazid (INH) toxicities
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hepatic, peripheral neuropathy
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what does rifampin look like
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GIANT
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Rifampin (RIF) dosing
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10mg/kg (2x/wk??), max 600mg qd
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Rifampin (RIF) toxicities
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hepatic, hematologic, flu-like symptoms
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Isoniazid and Rifampin pediatric dose
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10-20 mg/kg
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Ethambutol (EMB) dosing
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15-25 mg/kg or 50mg/kg 2x/wk (Max 800-1600mg 2.5g/day)
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Ethambutol (EMB) toxicities
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optic neuritis
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Ethambutol pediatric dose (EMB)
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15-25mg/kg
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Pyrazinamide (PYZ) dosing
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15-30mg/kg/day or 50-70 mg/kg*2x/wk (max 1-2g or 2g/day)
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pyrazinamide (PYZ) childrens dosing
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15-30 mg/kg
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pyrazinamide (PYZ) toxicities
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hepatic, hyperuricemia, gout
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rifamixin indication
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travellers diarrhea or maybe C diff
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Rifa type ADME
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CNS 12-25%, 3A4 inducer, (3x/week)
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1st to remove for mypopathy
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isoniazid (INH)]
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first two months of tb treatment
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isoniazid+rifampin+(ethambutol)+pyrazinamide
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continuing treatment for months 3-7(or 9)
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isoniazid+rifampin+(ethambutol)
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substitution in HIV
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replace rifampin with rifabutin (less of an enzyme inducer)
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regimen for daily TB
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isoniazid daily or twice weekly for 9 months (sometimes six months) OR rifampin daily for 4 months
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