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28 Cards in this Set
- Front
- Back
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ECHINOCANDINS
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caspofungin, anidulafungin, micafungin (about 20 member ring with an aliphatic chain)
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echinocandin MOA
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inhibit biosynthesis of b-d-glucan, essential in cell wall of filamentous fungi
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echinocandin resistance
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in the glucan synthase
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caspofungin spectrum
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aspergillus, candida (especially micafungin), aspergillus (but anidulafung 8X more potent)
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echinochandin DME
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low clearance, long half lives, andulafungin all excreted in feces
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andilofungin prep
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mixing in alcohol+others solvent
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caspofungin dose
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loading 70mg over 1 hour the 50mg qd
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micofungin dosing
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150mg/day over 1 hour (prevention in stem cell transplant >> 50mg/day
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aspergillosis DOC
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voriconazole
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aspergillosis 2nd line
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amph B or caspofungin, mycofungin/ anidulafungin or itraconazole/posaconazole
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aspergillus prophylaxis DOC
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posaconazole
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aspergillus prophylaxis 2nd line
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itraconazole or micafungin/anidulofungin
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oral esophageal candidiasis DOC
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fluconazole 100-200mg QD or caspofungin/micafungin
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oral esophageal candidiasis 2nd line
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voriconazole or intraconazole or Amph B
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vulvavaginal candidiasis DOC
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topical azoles or oral flucanazole (x1)
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vulvavaginal candidiasis 2nd line
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oral itraconazole, ketocoonazole
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candidemia DOC
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flucanazole 800mg load & 400mg QD
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candidemia 2nd line
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caspfungin/micafungin
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UTI candidiasis DOC
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fluconazole 200-400mg QD or aph B (lipid form)+flucytosine 25mg/kg
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UTI candidiasis 2nd line
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voriconazole
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cryptococcosis prophylaxis DOC
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amph B + flucytosine (2 weeks) then fluconazole orally for 8 weeks
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cryptococcosis prophylaxis 2nd line
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intraconazole, amph B
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onychomycosis DOC
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terbinafine or itraconazole orally
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onychomycosis 2nd line
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griseofulvin
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tinea pedis DOC
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terbinafine or clotrimazle/miconazole/eonazole
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terbinafine indication
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oral treatment of toenail or fingernail
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griseofulvin indication
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DOC for tinea barbae and tinea capitis, fungal infections of nails
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topical antifungals
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amph B and nystatin
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