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6 Cards in this Set
- Front
- Back
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Define primary ovarian insufficiency.
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<=40yrs old:
menstrual dysfunction (amen/oliogomen/dub) x 3 months 2 x FSH values >40mIU/ml 4 weeks apart (Williams gyne) hypergonadotropic hypogonadism |
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What is the incidence of POI in women younger than 40yo?
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1%
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What is the rate/percentage of spontaneous ovulation and conception in women diagnosed with POI?
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5-10%
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List causes of primary ovarian insufficiency.
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Oocyte loss/atresia
Turners or X-chromosome mosaicism FMR1 premutation Autoimmune ooprhitis (adrenal, thyroid) Infection (CMV, Mumps) Chemotherapy (Cyclophosphamide, Doxorubicin) Radiation (2Gy LD50 oocyte) Galactosemia Unresponsive Oocytes Steroidogenic enzyme defects (e.g. 21-hydroxylase, StAR) FSH receptor mutations |
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What is the incidence of FMR1 premutation in women with a familial history of primary ovarian insufficiency?
With sporadic (non-familial) POI? |
a) 15%
b) 2-5% |
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What is the most common cause of POI?
What is the critical reason for doing a karyotype in individuals with POI, even |
Gonadal dysgenesis
- 45X and variants, mosaics - 46XX pure gonadal dysgenesis - 46XY (Sywer) |
