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5 Cards in this Set
- Front
- Back
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Receptors |
Are very special macro molecules which are presented within our bodies and different ligands worked on them. |
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Ligands |
Mean the substances which bind with specific receptors. |
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Ligands |
1_ Hormones 2_ Neurotransmitters 3_ Drugs 4_Toxins 5_ Chemical substances |
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G protein |
A unique type of intracellular primary protein to which GTP or GDP binds . |
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How G protein works 1_Ligand bind with the receptor 2_ Ligand binding domain is loaded 3_ Receptor undergoe the change 4_ This stimulates effector domain 5_ Effector domain stimulates G protein a sub unit 6_ A subunit throw the low energy molecule ( GDP) 7_ And become rich with the high energy molecule (GTP) 8_ When it's rich no more interested with his long friends B & £ ; pull his hand and put it in the pocket; he doesn't want any relation & detach.
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9_ Friends which are B & £ were very sad they always with each other but A subunit detouch 10_ And developed a new relationship with a very clever protein which is A.C ( Adenylate Cyclase) and stimulate it ; as soon as a subunit stimulate A.C ; A.C effector unit becomes active; it breaks down the ATP into CAMP 11_ |
