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9 Cards in this Set
- Front
- Back
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what are the 3 endogenous catecholamines?
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epinephrine, norepinephrine, dopamine
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what are the precursors to dopamine? norepinephrine?
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tyrosine (amino acid) -> DOPA (BBB permeable) -> dopamine -> norepinephrine
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difference between NE and epi?
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norepi: primary ntm of adrenergic NS, neuronal
epi: leads to NE release, stored in adrenal glands, humoral |
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what do you know about nicotinic receptors?
(i.e. classification, ligand, mechanism, subtypes) |
-parasympathetic, ACh receptor
-always stimulatory -sodium ion channel -requires 2 ACh -in both CNS and ANS |
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what do you know about muscarinic receptors?
(i.e. classification, ligand, mechanism, subtypes) |
-parasympathetic
-g-protein linked M1: -stimulatory (increased cGMP) -in secretory cells (stomach, GI, lungs) M2: -inhibitory via potassium efflux and decreased cGMP -slows the heart |
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what do you know about alpha 1 receptors?
(i.e. classification, ligand, mechanism, effects) |
sympathetic
stimulatory increases IP3, DAG, calcium leads to smooth muscle contraction (vasoconstriction) |
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what do you know about alpha 2 receptors?
(i.e. classification, ligand, mechanism, effects) |
sympathetic
inhibitory decreases IP3, DAG, calcium shuts signal off (negative feedback) |
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what do you know about beta 1 receptors?
(i.e. classification, ligand, mechanism, effects) |
sympathetic
stimulatory increases cAMP, calcium cardiac! increases HR and contractility |
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what do you know about beta 2 receptors?
(i.e. classification, ligand, mechanism, effects) |
sympathetic
in eye, SA node, lung (think lung!) inhibitory in smooth muscles (lungs!) stimulatory in heart muscles |
