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22 Cards in this Set

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Pituitary Tumors
Prolactin secreting
Non Secreting
GH
ACTH
women w/amenhorrea, galctorrhea

men w/ED
prolactin secreting pituitary tumor
(inhib's est & testost)

tx w/DA
HA, vis field deficit, decreased GH

diabetes insipidus
hypothalamus tumor
HA, vis field deficit, decreased GH
non secreting pituitary tumor

tx w/surgery
dx w/MRI
kids with gigantism
adults w/acromegally (increased hat & shoe size)

elevated insulin like GF
GH secreting pit tumor

tx w/somatostatin
treatment of GH secreting tumor
somatostatin
hypercortisol sx's w/normal adrenal gland, normal hypothalamus, normal aldosterone
ACTH secreting pit tumor

tx w/surgery
Thyroid tumors
papillary (most common, best OC)
-ground glass nodules
follicular (responds like pap)
medullary (worst)- calcitonin
Anaplastic
lymphoma
calcitonin is tumor marker for...
medullary thyroid
-from cheif cells

common w/MEN2
thyroid tumor comon w/MEN2
medullary
increased Ca

"Bones, Moans & Psych Overtones"
hyperparathyroid tumor

(80% are adenoma)

can give DI b/c Ca dmg aquaporins
Pancreatic tumors
endocrine= insulinemia, gastrinoma, glucagon secreting, VIP

exocrine= high mortality
Pancreatic endocrine tumors
insulinoma
-eat a lot (esp late at nite)

Gastrinoma
-peptic ulcer dz
-tx w/surgery & PPI's

glucagon secreting
-glucose intol
-diarrhea

VIP secreting
-diarrhea
Adrenal adenomas
cortisol secreting
-high cort, low ACTH
-sx's like Cushings

Aldosterone secreting
-high ald, low renin
-HTN & HypoK

Pheochromocytoma
-HTN, sweaty, tachy, palp, ortho hypo, doom
-medullary pancreas

MEN1
HA, HTN, doom
pheochromocytoma
MEN 1 tumors affect
3 P's
-pancreas (gastrin "Z-E")
-pituitary (vis & GH)
-parathyroid (kidney stones)

kidney stones,
inheritance w/Men tumors
auto dom
MEN tumor w/kidney stone & stomach ulcer
type I

"wermers"

tumor suppressor gen mutation
MEN w/ongogene activated
MEN 2 & 3 (aka 2 b)

"Sipple's"

ret gene
MEN assoc's w/medullary thyroid and/or pheo
MEN 2 & 3 (aka 2 b)
MEN associated w/zollinger ellison
MEN 1
3 paraneoplastic syndromes
PTH related peptide
-assoc w/squamous cell

ADH secretion
-assoc w/sm cell carcinoma

ACTH secreting
-aggressive