Rbc Inclusions

Front 1

Howell-Jolly bodies

Back 1

Nuclear DNA fragment:

• Remnant of nucleous (DNA)
• Single or multiple
• Associated: Pernicious, hemolytic, rushed erythropoiesis, post splenectomy,
• Seen in Wright's stain and supravital stains
• Special stain: fuelgen

Front 2

Heinz bodies

Back 2

Denatured Hgb, unstable Hgb, G6PD deficiency

Associated Disorders:

• G6PD def or other enzymes of the hexosemonophosphate shunt
• Ingestion of oxidation drugs: hemolytic anemia
• fava bean cause hemolysis in G6PD def
• No seen in wright stain
• bite cell in wright stain
• Visible by supravital stain

Front 3

Basophilic stippling

Back 3

Precipitation of ribosomes DNA

Associated with:

• Thalassemia
• Lead poisoning
• Megaloblatic anemia
• Abnormla heme synthesis
• See with wright stain and supravital stains

Front 4

Pappenheimer bodies

Back 4

Iron, sideroblastic granules

Single or clusters

Associated with:

• Impaired Hgb Synthesis
• hemolytic anemia
• hemoglobinpathies
• post splenectomy
• seen in wright stain
• Called Siderotic granule in prussian blue stain

Front 5

Nucleated RBC

Back 5

Nucleus present

• Immature RBC
• Associated with hemolytic anemia
• Normal infants
• rushed erythoropoeisis

Front 6

Cabot rings

Back 6

spindle material in abnormal mitosis

remnant of nuclear material

seen in nucleated and non nucleated cells

Associated with:

• Severe anemia
• Following splenectomy
• lead poisoning
• seen in wright stain and supravital stain

Front 7

Malarial Parasite

Back 7

Presence of parasite: P. falciparum, malariae, vivax, ovale

Sporozoa of genus plasmodium

Front 8

Grading Inclusions

Back 8

1/OIF= few

2-3/OIF=1+

4-8/OIF=2+

9-12/OIF=3+

>13=4+

Front 9

Back 9

basophilic stippling

Front 10

Back 10

Cabot ring

Front 11

Back 11

Heinz body

Front 12

Back 12

Howell-Jolly Body

Front 13

Back 13

Pappenheimer bodies

Front 14

Back 14

Bite cell

Heinz body (wright stain)