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25 Cards in this Set
- Front
- Back
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Bands that run with S on Cellulose and with A on citrate
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Hb-D (Beta chain defect) & Hb-G (Alpha chain defect)
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Patient of Meditarranean descent with Hb-S <30% and Hb-F ~20%
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Hb-Lepore (delta & Beta gene fusion)
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What's Hb-Constant Spring?
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Alpha gene defect (produces alpha Thal)
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What's Hb with Fe+++ (instead of Fe++)?
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Methemoglobin: (Can't bind O2)
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Best way to detect Met-Hemoglobin
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Co-oximeter
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Common causes of aquired Met-Hb
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Nitrites, Quinones, Phenacetin, Sulfonamides
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Tx of Acquired Met-Hb?
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Methylene Blue (Met-Hb ---> Hb)
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Causes of Sulf-Hb
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Sulfonamides and C. perfringens (Sulf-Hb is an irreversibly oxidized Hb)
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Alpha and Beta chain genes of Hb are on which chromosomes?
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Alpha= Chr 16 (usually large deletions) and Beta= Chr 11 (mostly point mutations)
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What's typical Thal index (MCV/#RBC) for Fe-def?
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>15
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Electropheresis and Lab findings in Alpha-Thal trait
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Normal Electropheresis but with a Thal. Index of <13
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Geogphraphy of alpha-Thal vs Beta-Thal
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Alpha-Thal: Africa nd Asia, Beta-Thal: Meditarranean
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Dx of Hb-Electropheresis showing Elevated A2 and Normal Hb-F
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Beta-Thal (note: If Hb-A2 is Normal, you can't assume Alpha-thal until you rule out Fe-def)
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Electropheresis findings of B-Thal major
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Elevated Hb-A2, Very elevated Hb-F (50-95%), and very low Hb-A
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Common causes of secondary AIHI
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CLL/SLL or other lymphomas, Autoimmune Diseases, Collagen vascular disease, Thymoma
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The only reliable CBC index that can be reported in the setting of cold agglutinins
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Hb
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Pathological vs Nonpathological Cold Agglutinin
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Pathological (Broad thermal range and High titers)
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Diseases associated with the following cold agglutinins; Anti-I and Anti-i
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Anti-I: M. pneumoniae and Anti-i: EBV-mononucleosis
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Dx of child post viral illness with severe anemia & "Biphasic Hemolysin Ab test"
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PCH (Paroxysmal Cold Hemoglobinuria): + Donath Landsteiner test (Hemolysis at 4 and 37 degrees C)
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Most common type of Cryoglobulinemia
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Type II: Monoclonal IgM (Rh factor activity Anti-IgG) and polyclonal IgG
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Most common cause of mixed Cryoglobulinemia
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Type II and Type III (HCV)
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Significance of increased Zinc Protoporphyrin and Free Erythrocyte Protoporphyrin
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Seen in Fe-def. anemia, Lead poisoning and Anemia of Chronic Disease
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Amount of Fe in 1ml of RBC
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1 mg
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Lab findings in B12 deficiency
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Increased Urinary MMA, Decreased B12 and Increased MCV
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Active form of folate and what's needed for its conversion?
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THF which needs B12
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