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15 Cards in this Set
- Front
- Back
what is the next step
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per smear
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clinica
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lab tests
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accumulation of myelocyte cells-- spike
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lab
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ds
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2 % is philadephia negative , this is much worse
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molecular
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natural course
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blast crisis is secondary acute leukemia. all of them will do this eventually
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what could be trigger for acceleration phase
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chronic phase
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accelerated phase
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basophils could be up to 18 %
from this phase patients are going to blast crisis |
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blast crisis is acute leukemia
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tx
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interferon show the suppression if 9-22 and prolong the chronic phase
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imatinib
p have cytogenetic remission with this drug |
side effects- few , some rash some edema and GI
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bone marrow trns
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how can you differen lekemoid reaction and CML on periferal blood
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cannot
sudden elevation in total leukocytes counts and marked increased of granulocytes precursors( lefr shift) tell us about severe inflammation leukocyte alkaline phosphotase will be increased in leukemoid reaction presence of philadelphia chromosome should be helpful(она есть при лейкемии) |
