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5 Cards in this Set
- Front
- Back
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definiton
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cold agglutinins are Ig M against red cells developing in association with EB virus
mycoplasma waldensrom macroglobulinemia troponasomia malaria may idiopatic in some elderly |
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present
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symptoms are in cold parts of body
nose earls fingers toes symptoms are resolved on warming up symptoms are worse from idiopathic or lymphoma but mild from infection |
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ds
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1 positive agglutinis
2direct Coomb tes is positive only for complemet, standart Coomb test is negative 3 smear is Normal 4 may be spherocytosis 5 jundice |
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tx
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stay warm
rituximab- mononclonal antibody that binds to CD20, INCLUDING THE COMPLIMENT OR ANTIBODY -MEDIATED CYTOLYSIS transfuse if need with warm blood plasma exnge in critrical cyclophosphamide ( metabolites interfere with malignant cell growth by cross- linking DNA of tumor cells) cyclosporine ( calcineurin ingibitor, supress celular and humoral immunity - mainly T cells) or ther immunosupress for stop the prod of antibodies |
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tips
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steroid and splenoectomy or Iv immunoglobuln-- no value
prednisone is the most wrong answer |
