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5 Cards in this Set

  • Front
  • Back
definiton
cold agglutinins are Ig M against red cells developing in association with EB virus
mycoplasma
waldensrom macroglobulinemia
troponasomia malaria may idiopatic in some elderly
present
symptoms are in cold parts of body
nose
earls fingers toes
symptoms are resolved on warming up
symptoms are worse from idiopathic or lymphoma but mild from infection
ds
1 positive agglutinis
2direct Coomb tes is positive only for complemet, standart Coomb test is negative
3 smear is Normal
4 may be spherocytosis
5 jundice
tx
stay warm
rituximab- mononclonal antibody that binds to CD20, INCLUDING THE COMPLIMENT OR ANTIBODY -MEDIATED CYTOLYSIS
transfuse if need with warm blood
plasma exnge in critrical
cyclophosphamide ( metabolites interfere with malignant cell growth by cross- linking DNA of tumor cells)
cyclosporine ( calcineurin ingibitor, supress celular and humoral immunity - mainly T cells) or ther immunosupress for stop the prod of antibodies
tips
steroid and splenoectomy or Iv immunoglobuln-- no value
prednisone is the most wrong answer