Ravilya2013 Anemia Of Chronic Disease

Front 1

Anemia of chronic disease is generally associated with conditions that release

Back 1

Anemia of chronic disease is generally associated with conditions that release cytokines
(tumor necrosis factor–α, interleukin-1, and other inflammatory cytokines). These
cytokines decrease erythropoietin production, decrease the levels of iron released from the
reticuloendothelial system, and increase serum ferritin levels.

Front 2

Administration of erythropoietin
in pharmacologic doses corrects the anemia of chronic disease by

Back 2

Administration of erythropoietin
in pharmacologic doses corrects the anemia of chronic disease by compensating
for the decreased production of erythropoietin

Front 3

Anemia of Chronic Disease Definition.

Back 3

Definition. A defect in the ability to make use of iron sequestered in stores within the reticuloendothelial
system. It can be either microcytic or normocytic

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Anemia of Chronic Disease etiology

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elevated hepsidin- protein made by liver inhibins iron transfer from macrophages to bone marrow and inhibits absorbtion of iron from the intestine

Etiology.Anemia can accompany virtually any chronic inflammatory,infectious,or neoplastic
condition.

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Anemia of Chronic Disease
ds

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Diagnosis. The serum ferritin levelis normal or elevated. The serum iron level and total iron
binding capacity (TIBC) are both low. The reticulocyte count is low.

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Anemia of Chronic Disease gold st in ds

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gold standart in ds is bone marrow biopsy( showing macrophages that stain densely with prussian blue- dues to secuestered stores

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Anemia of Chronic Disease tx

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Treatment. Correct the underlying disease. Iron supplementation and erythropoietin will not
help, except in renal disease and anemia caused by chemotherapy or radiation therapy for
malignancies

Front 8

Anemia of Chronic Disease when to tranfuse

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only if symptom or very severe