Reading...
Play button
Play button
Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
9 Cards in this Set
- Front
- Back
|
Amyloid cardiomyopathy
|
Amyloid cardiomyopathy
is most often caused by deposition of monoclonal light chain fragments in the myocardium forming stiff, β-pleated sheets. Thus, primary amyloidosis is seen in plasma cell dyscrasias such as multiple myeloma, which . Amyloid cardiomyopathy in the setting of multiple myeloma might also present with hypercalcemia and bone pain. |
|
|
characteristically causes on x-ray
|
characteristically causes “punched-out” lytic
bone lesions on x-ray |
|
|
POEMS syndrome
|
presenting
with POEMS syndrome, a constellation of symptoms associated with osteosclerotic multiple myeloma. Symptoms include Polyneuropathy, Organomegaly, Endocrinopathy, Multiple myeloma, and Skin changes. Polyneuropathies are generally progressive sensorimotor deficits. Hepatosplenomegaly is generally seen, in contrast to other myeloma patients. Endocrine manifestations include amenorrhea, diabetes mellitus, hypothyroidism, and adrenal insufficiency. Skin changes are diverse, but may include hyperpigmentation, hypertrichosis, thickening, and digital clubbing |
|
|
POEMS syndrome...Polyneuropathies
|
Polyneuropathies are generally progressive sensorimotor
deficits. |
|
|
liveR/POEMS syndrome
|
Hepatosplenomegaly is generally
seen, in contrast to other myeloma patients. |
|
|
POEMS syndrome
Endocrine manifestations |
Endocrine manifestations include
amenorrhea, diabetes mellitus, hypothyroidism, and adrenal insufficiency. Skin changes are diverse, but may include hyperpigmentation, hypertrichosis, thickening, and digital clubbing |
|
|
POEMS syndrome
Skin changes |
Skin
changes are diverse, but may include hyperpigmentation, hypertrichosis, thickening, and digital clubbing |
|
|
POEMS syndrome
her peripheral blood smear |
her peripheral blood smear
demonstrates a large number of plasma cells, as are seen in multiple myeloma. In addition, her laboratory work reveals anemia, hyperuricemia, and hypercalcemia, all consistent with a diagnosis of multiple myeloma. This diagnosis can be confirmed by the presence of an M spike on protein electrophoresis of urine and serum |
|
|
POEMS syndrome l
aboratory work reveals |
In addition,
her laboratory work reveals anemia, hyperuricemia, and hypercalcemia, all consistent with a diagnosis of multiple myeloma. This diagnosis can be confirmed by the presence of an M spike on protein electrophoresis of urine and serum |
