Rav Hemo Kaplan Waldstrom Macroglob..emia

Front 1

what will see on histo

Back 1

see small lyphocytes with plasmacytoids lymphocytes and plasma cells, indolent (treat like indolent lymphoma).
fatigue, lymphadenopathy, bleeding.

Front 2

Unlike MM,what is there

Back 2

Unlike MM, there's hyperviscosity and no lytic bone pain

Front 3

clinical

Back 3

indolent (treat like indolent lymphoma).
fatigue, lymphadenopathy, bleeding.

Front 4

Most patients
with this disease present with symptoms

Back 4

Most patients
with this disease present with symptoms
of hyperviscosity (Raynaud’s phenomenon and
visual disturbances), and protein-protein interaction
(platelet dysfunction).

Front 5

Diagnosis requires

Back 5

Diagnosis requires
the demonstration of an IgM spike on
plasma electrophoresis, as well as infiltration of
bone marrow with plasmacytoid lymphocytes.

Front 6

to control hyperviscosity... how to

Back 6

Plasmapheresis is used to control hyperviscosity
initially because response to chemotherapy
can take several weeks.

Front 7

Treatment regimens involve

Back 7

Treatment regimens involve
the same chemotherapeutics as those
used for multiple myeloma, including alkylating
agents and prednisone. Overall mean survival
is 5 years