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19 Cards in this Set
- Front
- Back
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acute hemolytic trans reaction
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occurs within minutes or hours of exposure
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by what will be intravascular destruction caused
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compliment activation
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by what will be extravascular destruction caused
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without complement activation
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symptoms of acute hemolytic reaction
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fever chest pain
Wheezing back pain hypo tension DIC bleeding renal impairment |
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tx of acute all react fro trans
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stop transf
correct hypotension control bleeding prevent acute renal failure ( use iv fluid mannitol diuretics to maintain output at 100 CC / hr follow bank protocol for returning the unit and checking urine and serum |
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febrile non hemol transf reaction
descrpti.. |
occurs min or hours of exposure
in 0.5 % relatively common less common because most units of pRBC are not filtered |
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febrile non hemol transf reaction
symptoms |
transient flushing
palpitation tachycardia cough chest discomfort neutropenia latent period of 15-60 min then increased BP, headache chills rigors |
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febrile non hemol transf reaction
pathology |
cyto toxic or agglut antibodies from prior transfusion, reacting to transfused WBC
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febrile non hemol transf reaction
tx steps |
stop tranf
test for hemolysis antipyretics WBC filter if not already done |
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acute lung injury descript
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infrequent
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acute lung injury symptoms
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fever chest pain
dyspnea cyanosis cough blood tingled sputum hypoxemia resemble CHF , but not cardiogenic |
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acute lung injury pathology
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anti human lymphocyte antigen( HLA)
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acute lung injury tx steps
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respir support
mechanica ventil fluid replacement |
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allergic reaction
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urticaria and pruritis is i 1%
thi si reaction between donor protein and patient immunoglubulin E (IgE) usually mild anaphylaxis is rare |
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delaeyd reaction for transfusion
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reaction occurs days after
AB occurs as anamnestic response history of previous transf or pregnancy positive coomb test |
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graft versus host disease
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reaction in immunocompromised patient or in P getting tx for lymphoma or leukemia
4- 30 days after transfusion fever erythema diarrhea LFT abnorm, pancytopenia mortality 84% pathology T lymphocyte mediated prevention_- pretranf irradiation of blood or components in high risk patienst |
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irod overload
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hemochromatosis
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post tranf purpura
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tthrmbocytoenia 5-9 days after transfusion
pathology-- alloantibodies to platele antigen tx- steroids Iv GammaGlob plasma/ blood exchange |
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transfusion- transmitted infection
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hep C- common.. 7-8 weeks after transfusion. 50 % will develop chronic hepatitis
10-20% -- will get cirrosis or HCC aim for prevention with donor screening retro viral infection--- 3 % of AIDS from transfusion seven years latency, aim for prevention with donor screening CMV- if immunocompetent- inf is not serious, BM recipients may be more severe affected and e should be testes and receive CMV negative blood new cases are rare |
