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19 Cards in this Set
- Front
- Back
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defenition
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noinregulated overproduction of all 3 cell lines, but red cell overproduction is most prominent
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where is mutation
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jak2 protein with regulate BM production
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what is EPO level
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despite red cells grow EPO will ve low
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what is most likely diagnosis
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hyperviscocity from the increased red blood cell mass as
head ache blurred vision tinntitis HTN fatique splenomegaly bleeding from engorged blood vessels thrombosis from viscosity |
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why pruritis
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histamin ... from basoiphiles
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ds
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HCT is elevated above 60 %
plateles and WBC also up exlude hypozia total RBC is up OXYGEn level is normal EPO is low vitr b12 is uo for unknow reason iron level is low---it was used to make RBC |
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most accurate test
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Jak 2 mutation dound in 95 %
increased basophills |
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maligization?
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some Ps can convert to AMl
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MCV
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low
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tx
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phlebothomy
hydroxyurea ( helps lower the cells count) |
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what wll be Hb
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male- >18.5
fem/ 16.5 thrombocytosis > 400.000 WBC > 12.000 |
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signs
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splenomegaly
bleeding thrombotic events- mesenteric |
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symptoms
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hyperviscocity ... TIA/ stroke
pruritis head ache dyspnea blurry vision |
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best initial test
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.serum EPO
if normal--> secondary polycyithemia if increased l>>>get bone marrow biopsy>>>> pan myelosis if EPO decreased>>> primary polycythemia virtually almost 100 % of primary casesare jakj2 positive if both exon12 and exon14 tested |
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defenition
|
noinregulated overproduction of all 3 cell lines, but red cell overproduction is most prominent
|
|
|
where is mutation
|
jak2 protein with regulate BM production
|
|
|
what is EPO level
|
despite red cells grow EPO will ve low
|
|
|
what is most likely diagnosis
|
hyperviscocity from the increased red blood cell mass as
head ache blurred vision tinntitis HTN fatique splenomegaly bleeding from engorged blood vessels thrombosis from viscosity |
|
|
why pruritis
|
histamin ... from basoiphiles
|
