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19 Cards in this Set

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  • Back
defenition
noinregulated overproduction of all 3 cell lines, but red cell overproduction is most prominent
where is mutation
jak2 protein with regulate BM production
what is EPO level
despite red cells grow EPO will ve low
what is most likely diagnosis
hyperviscocity from the increased red blood cell mass as
head ache
blurred vision
tinntitis
HTN
fatique
splenomegaly
bleeding from engorged blood vessels
thrombosis from viscosity
why pruritis
histamin ... from basoiphiles
ds
HCT is elevated above 60 %
plateles and WBC also up
exlude hypozia
total RBC is up
OXYGEn level is normal
EPO is low
vitr b12 is uo for unknow reason
iron level is low---it was used to make RBC
most accurate test
Jak 2 mutation dound in 95 %
increased basophills
maligization?
some Ps can convert to AMl
MCV
low
tx
phlebothomy
hydroxyurea ( helps lower the cells count)
what wll be Hb
male- >18.5
fem/ 16.5
thrombocytosis > 400.000
WBC > 12.000
signs
splenomegaly
bleeding
thrombotic events- mesenteric
symptoms
hyperviscocity ... TIA/ stroke
pruritis
head ache
dyspnea
blurry vision
best initial test
.serum EPO
if normal--> secondary polycyithemia
if increased l>>>get bone marrow biopsy>>>> pan myelosis
if EPO decreased>>> primary polycythemia
virtually almost 100 % of primary casesare jakj2 positive if both exon12 and exon14 tested
defenition
noinregulated overproduction of all 3 cell lines, but red cell overproduction is most prominent
where is mutation
jak2 protein with regulate BM production
what is EPO level
despite red cells grow EPO will ve low
what is most likely diagnosis
hyperviscocity from the increased red blood cell mass as
head ache
blurred vision
tinntitis
HTN
fatique
splenomegaly
bleeding from engorged blood vessels
thrombosis from viscosity
why pruritis
histamin ... from basoiphiles