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7 Cards in this Set
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the common drug induced thrombocytopenia
pathphys |
HIT is the common drug induced thrombocytopenia
antibody bind to complex formed by heparin and platelet factor 4PF4 with is found in the alfa granules of platelets |
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when could it occur
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condition can occurs after 5-10 days of exposure in intravenous infractionated heparin and it can also occur after subcutaneous unfractionated heparin or LMWH is administered
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how procoagulants will be released
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antibody PF4 complexes may release procoagulants from activated platelets in to the circulation. venous and arterial clots can occur
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tx
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all heparin containing products should be stop immediately in patients with HIT and anticoagulation with a direct thrombin inhibitor ( argatroban or lepiridin) bivalirudin
walwarin should be avoided wihtout other anticoagulants in P with HTP >> may increased risk for gangrenein P with DVT |
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when will be resolution
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resolution after 4-5 days of discontunuation of heparin
thombocytopenia- Adverse affect elevated PTT is therapeutic effect of heparin |
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how to regulate the anticoagulation with heparin
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with aptt
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LMWH inhibits what factor
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Xa with reduce thrombin inhibitory effect
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