Rav Hemo Factor V Def

Front 1

hereditary disorders
of the coagulation system. Factor V Leiden
is an autosomal dominant disorder in
which

Back 1

hereditary disorders
of the coagulation system. Factor V Leiden
is an autosomal dominant disorder in
which coagulation factor Va (the activated
form of coagulation factor V) is resistant to
degradation by activated protein C.

Front 2

how could f V promote hypercoagulable state in patients.

Back 2

Factor Va
remains active and allows for the conversion of
prothrombin to thrombin, thereby promoting a
hypercoagulable state in patients.

Front 3

The relative risk of venous
thrombosis in a patient with a heterozygous
mutation of the gene encoding factor V

Back 3

Factor V
Leiden accounts for 40–50% of venous thromboemboli
in cases in whom a genetic predisposition
is found. The relative risk of venous
thrombosis in a patient with a heterozygous
mutation of the gene encoding factor V is 7,
and that in a patient with the mutation in conjunction
with concomitant oral contraceptive
use is 3