Hematology Cml3

Front 1

Chronic myelogenous
leukemia (CML), in its chronic phase,
presents with

Back 1

Chronic myelogenous
leukemia (CML), in its chronic phase,
presents with constitutional symptoms along
with abdominal fullness due to splenomegaly.
Diagnosis is most common in the fourth to
sixth decades of life, and irradiation increases
the risk of developing CML. Because it is a
proliferation of mature myeloid cells, peripheral
smear should show predominant leukocytosis
with cells in all stages of maturation. Definitive
diagnosis relies on identification of the
Philadelphia chromosome or the bcr-abl fusion
product. However, approximately 5% of
patients have atypical CML without presence
of bcr-abl and show a poor response to therapy.

Front 2

Diagnosis is most common in

Back 2

Diagnosis is most common in the fourth to
sixth decades of life, and i

Front 3

what is increases
the risk of developing CML

Back 3

rradiation increases
the risk of developing CML.

Front 4

smear should show

Back 4

Because it is a
proliferation of mature myeloid cells, peripheral
smear should show predominant leukocytosis
with cells in all stages of maturation.

Front 5

Definitive
diagnosis

Back 5

Definitive
diagnosis relies on identification of the
Philadelphia chromosome or the bcr-abl fusion
product. However, approximately 5% of
patients have atypical CML without presence
of bcr-abl and show a poor response to therapy.

Front 6

what % of patients have atypical CML without presence
of bcr-abl and show a poor response to therapy.

Back 6

However, approximately 5% of
patients have atypical CML without presence
of bcr-abl and show a poor response to therapy.

Front 7

bone marrow,

Back 7

. CML
may show hypercellularity of the bone marrow,
as well as differentiated cells rather than blasts.
A bone marrow biopsy will not, however, differentiate
the type of leukemia. The diagnosis
of CML depends on cytogenetics.

Front 8

The diagnosis
of CML depends on

Back 8

The diagnosis
of CML depends on cytogenetics.