Rav Endocrinology . Hyperca And Sarcoidosis

Front 1

* The underlying mechanism of hypercalcemia in granulomatous diseases involves

Back 1

Treat hypercalcemia associated with sarcoidosis.
Key Point

* The underlying mechanism of hypercalcemia in granulomatous diseases involves excess production of 1α-hydroxylase, which converts 25-hydroxy vitamin D to 1,25-dihydroxy vitamin D; corticosteroid administration diminishes this hypercalcemia.

Front 2

With sarcoidosis, hypercalcemia may be secondary to increased

Back 2

With sarcoidosis, hypercalcemia may be secondary to increased intestinal absorption induced by excessive amounts of 1,25-dihydroxy vitamin D. In patients with this disorder, 1,25-dihydroxy vitamin D production can be diminished by using corticosteroids, such as prednisone, as the initial therapy.