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8 Cards in this Set
- Front
- Back
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ACTH deficiency causes
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hypocortisolism, with symptoms of nausea, vomiting, weakness, fatigue, fever, and hypotension.
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Mineralocorticoids are not generally affected by this deficiency because
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they are controlled by the renin-angiotensin system, so hyperkalemia is not present.
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In women, reduced adrenal androgens can
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decrease libido and cause loss of axillary and pubic hair.
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However, patients with significant ACTH and cortisol deficiency may occasionally
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be asymptomatic.
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The most common cause of ACTH deficiency is
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suppression of ACTH secretion with exogenous corticosteroids.
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If another cause is responsible, ACTH deficiency usually occurs in combination with
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the loss of other pituitary hormones.
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Acquired isolated ACTH deficiency can occur, however, particularly in
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women with lymphocytic hypophysitis.
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megestrol acetate for appetite stimulation can occasionally
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suppress the secretion of ACTH and lead to its deficiency.
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