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8 Cards in this Set

  • Front
  • Back
ACTH deficiency causes
hypocortisolism, with symptoms of nausea, vomiting, weakness, fatigue, fever, and hypotension.
Mineralocorticoids are not generally affected by this deficiency because
they are controlled by the renin-angiotensin system, so hyperkalemia is not present.
In women, reduced adrenal androgens can
decrease libido and cause loss of axillary and pubic hair.
However, patients with significant ACTH and cortisol deficiency may occasionally
be asymptomatic.
The most common cause of ACTH deficiency is
suppression of ACTH secretion with exogenous corticosteroids.
If another cause is responsible, ACTH deficiency usually occurs in combination with
the loss of other pituitary hormones.
Acquired isolated ACTH deficiency can occur, however, particularly in
women with lymphocytic hypophysitis.
megestrol acetate for appetite stimulation can occasionally
suppress the secretion of ACTH and lead to its deficiency.